Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital in Krakow, 30-688 Krakow, Poland.
Department of Internal Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland.
Medicina (Kaunas). 2024 Jan 13;60(1):149. doi: 10.3390/medicina60010149.
: Biochemical and molecular regulation of both adaptive and pathological responses of heart tissue to ischemic injury is widely investigated. However, it is still not fully understood. Several biomarkers are tested as predictors of left ventricle (LV) remodeling after myocardial infarction (MI). The aim of this study was to assess the relationship between selected microRNAs (miRNAs) and LV function and morphology in patients after MI. : Selected miRNAs related to heart failure were assessed in the acute phase of MI: miR-150-3p, miR-21-5p, miR-19b-3p, miR-155-5p, miR-22-5p. Echocardiography with 3D imaging was performed at baseline and after 6 months. Remodeling was defined as >20% increase in LV end-diastolic volume, whereas reverse remodeling was defined as >10% reduction in LV end-systolic volume. : Eighty patients entered the registry. Remodeling occurred in 26% and reverse remodeling was reported in 51% of patients. In the presented study, none of the analyzed miRNAs were found to be a significant LV remodeling predictor. The observed correlations between miRNAs and other circulating biomarkers of myocardial remodeling were relatively weak. : Our analysis does not demonstrate an association between the analyzed miRNAs and LV remodeling in patients with MI.
心脏组织对缺血性损伤的适应性和病理性反应的生化和分子调节得到了广泛的研究。然而，人们仍然不完全了解。一些生物标志物被测试为心肌梗死 (MI) 后左心室 (LV) 重构的预测因子。本研究旨在评估 MI 后患者选定 microRNAs (miRNAs) 与 LV 功能和形态之间的关系。
在 MI 的急性期评估了与心力衰竭相关的选定 miRNAs：miR-150-3p、miR-21-5p、miR-19b-3p、miR-155-5p、miR-22-5p。在基线和 6 个月时进行了具有 3D 成像的超声心动图检查。重构定义为 LV 舒张末期容积增加>20%，而逆重构定义为 LV 收缩末期容积减少>10%。
80 名患者进入登记册。26%的患者发生重构，51%的患者发生逆重构。在本研究中，未发现分析的 miRNAs 是 LV 重构的显著预测因子。miRNAs 与其他心肌重构循环生物标志物之间的观察到的相关性相对较弱。
我们的分析并未表明 MI 患者分析的 miRNAs 与 LV 重构之间存在关联。
