Interdisciplinary Center for Clinical Research, University Hospital Würzburg, Germany; Institute for Molecular Infection Biology, University Würzburg, Würzburg, Germany.
Curr Opin Microbiol. 2019 Dec;52:41-46. doi: 10.1016/j.mib.2019.04.007. Epub 2019 May 25.
The yeast Candida albicans inhabits the gastrointestinal tract of most healthy adults, seemingly living there as a harmless commensal. The fungus on occasion disseminates from the gut to other internal organs causing life-threatening infections. Here, I review some of the most exciting advances in the study of gut colonization by C. albicans in the last few years. These developments highlight the close interplay between C. albicans and cohabiting microbes, the responses that commensal fungi elicit from the mammalian host, and the genetic determinants that allow the fungus to thrive in such a crowded and demanding ecosystem.
白色念珠菌（Candida albicans）是一种存在于大多数健康成年人胃肠道内的酵母，通常作为一种无害的共生菌存在。这种真菌有时会从肠道传播到其他内部器官，导致危及生命的感染。在这里，我回顾了过去几年中关于白色念珠菌在肠道定植的一些最令人兴奋的进展。这些进展突出了白色念珠菌与共生微生物之间的密切相互作用、共生真菌对哺乳动物宿主的反应，以及使真菌在如此拥挤和苛刻的生态系统中茁壮成长的遗传决定因素。
