组胺 H4 受体基因多态性：梅尼埃病的潜在致病因素。
Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease.
机构信息
Inpatient Department 7th floor District 6, Dongjie Branch of Quanzhou 1st Hospital, Quanzhou 1st Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China.
Inpatient Department 10th floor District 13, Chendong Branch of Quanzhou 1st Hospital, Quanzhou 1st Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China.
出版信息
BMC Med Genomics. 2019 May 27;12(1):71. doi: 10.1186/s12920-019-0533-4.
BACKGROUND
The immune system is likely involved in the pathophysiology of Meniere's disease (MD). However, its role of patients with MD has not been well studied. Given that histamine H4 receptors are highly expressed in immune system, we tested the hypothesis that histamine H4 receptor gene polymorphisms are a potential contributor to the risk of MD.
METHODS
A group of patients was enrolled with a diagnosis of definite MD based on the American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium guidelines and a control group of patients without any vestibular disease. We selected one SNP, rs77485247 in HRH4 and conducted an exploratory investigation of its correlations with the symptoms of vertigo and proinflammatory cytokines levels in MD patients.
RESULTS
HRH4 rs77485247 polymorphism may be associated with the risk of MD. Furthermore, basal levels of proinflammatory cytokines, such as IL-1β and TNF-α, in PBMCs are increased in patients with MD compared to control patients. This increased basal level of proinflammatory cytokines is prominent in MD patients with the A allele.
CONCLUSIONS
These suggested that HRH4 rs77485247 polymorphism may be an important mediator in regulating proinflammatory cytokines, which are involved in the pathogenesis of MD.
背景
免疫系统可能参与梅尼埃病（MD）的病理生理学。然而，其在 MD 患者中的作用尚未得到充分研究。鉴于组胺 H4 受体在免疫系统中高度表达，我们检验了这样一个假设，即组胺 H4 受体基因多态性可能是 MD 发病风险的一个潜在因素。
方法
一组根据美国耳鼻喉科学-头颈外科学会委员会关于听力和平衡的指南诊断为明确 MD 的患者和一组无任何前庭疾病的对照组患者被纳入研究。我们选择了 HRH4 中的一个 SNP（rs77485247），并对其与 MD 患者眩晕症状和促炎细胞因子水平的相关性进行了探索性研究。
结果
HRH4 rs77485247 多态性可能与 MD 的发病风险相关。此外，与对照组患者相比，MD 患者外周血单个核细胞（PBMCs）中促炎细胞因子（如 IL-1β 和 TNF-α）的基础水平升高。在携带 A 等位基因的 MD 患者中，这种促炎细胞因子的基础水平升高更为显著。
结论
这些结果提示 HRH4 rs77485247 多态性可能是调节参与 MD 发病机制的促炎细胞因子的重要介质。
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