Tyrrell Jessica S, Whinney David J D, Ukoumunne Obioha C, Fleming Lora E, Osborne Nicholas J
1European Centre for Environment and Human Health, University of Exeter Medical School, The Knowledge Spa, Truro Campus, Cornwall, United Kingdom; 2Department of ENT Surgery, Royal Cornwall Hospital, Truro, United Kingdom; and 3PenCLAHRC, University of Exeter Medical School, Exeter, United Kingdom.
Ear Hear. 2014 Jul-Aug;35(4):e162-9. doi: 10.1097/AUD.0000000000000041.
The aims of this study were to estimate the prevalence of Ménière's disease and investigate its relationship with: demographic factors; symptoms and conditions that are known or hypothesized to be associated with Ménière's disease; other physical diseases; mental health.
The authors used cross-sectional data from the UK Biobank to compare 1376 self-reported Ménière's participants with over 500,000 without Ménière's. The data set has comprehensive anthropometric measures, questionnaire data investigating health, well-being, diet, and medical and drug-prescribing history for each participant. The authors used logistic regression models to investigate the relationship of Ménière's disease with: demographic factors; symptoms and conditions that are known or hypothesized to be associated with Ménière's disease; other physical diseases; and mental health.
Ménière's disease was more common in participants who were older (adjusted odds ratio per 10-year increase: 1.5 [95% confidence interval:1.4-1.6]), white (odds ratio: 1.7;1.2-2.3), female (1.4;1.3-1.6), and having higher body mass index categories (p < 0.001). The Ménière's group had greater odds of hearing difficulty (10.9;9.6-12.5), current tinnitus (68.3;47.8-97.5), and had fallen more than once in the last year (2.1;1.8-2.5). Ménière's participants had greater odds of reporting at least one disease from each grouping of allergic, immune dysfunction, or autonomic dysfunction (2.2;1.8-2.6), and poor mental health (2.1;1.8-2.5).
This study provides an evidence base that improves understanding of Ménière's disease. Associations were noted with a number of diseases, and the authors hypothesize a role for the autonomic nervous system and immune system dysfunction in Ménière's etiology. The study also highlights the physical and mental health correlates of the condition.
本研究旨在估计梅尼埃病的患病率，并调查其与以下因素的关系：人口统计学因素；已知或假设与梅尼埃病相关的症状和疾病；其他身体疾病；心理健康状况。
作者使用了英国生物银行的横断面数据，将1376名自我报告患有梅尼埃病的参与者与50多万名未患梅尼埃病的参与者进行比较。该数据集包含全面的人体测量指标、关于每位参与者的健康、幸福感、饮食以及医疗和用药史的问卷调查数据。作者使用逻辑回归模型来研究梅尼埃病与以下因素的关系：人口统计学因素；已知或假设与梅尼埃病相关的症状和疾病；其他身体疾病；以及心理健康状况。
梅尼埃病在年龄较大（每增加10岁调整后的比值比：1.5[95%置信区间：1.4 - 1.6]）、白人（比值比：1.7；1.2 - 2.3）、女性（1.4；1.3 - 1.6）以及体重指数较高的参与者中更为常见（p < 0.001）。梅尼埃病组出现听力困难的几率更高（10.9；9.6 - 12.5）、当前有耳鸣的几率更高（68.3；47.8 - 97.5），并且在过去一年中跌倒不止一次的几率更高（2.1；1.8 - 2.5）。梅尼埃病参与者报告在过敏、免疫功能障碍或自主神经功能障碍每组中至少有一种疾病的几率更高（2.2；1.8 - 2.6），心理健康状况较差的几率也更高（2.1；1.8 - 2.5）。
本研究提供了一个证据基础，有助于增进对梅尼埃病的理解。研究发现了梅尼埃病与多种疾病之间的关联，作者推测自主神经系统和免疫系统功能障碍在梅尼埃病的病因学中起作用。该研究还强调了这种疾病与身心健康的相关性。
