Chen Lu, He Yuna, Su Chang, Liu Tingting, Mao Hongmei, Yang Linli, Zhang Ronghua, Huang Lichun, Zhuo Qin
Key Laboratory of Trace Element Nutrition of National Health Commission( NHC) , National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310009, China.
Wei Sheng Yan Jiu. 2019 Mar;48(2):214-219.
To investigate the association between serum leptin concentration with blood pressure and hypertension in different gender.
A total of 343 non-hypertensive residents aged 30 to 65 were randomly selected from Zhejiang Province in 2014. Parameters including height, weight, waist, blood pressure, serum lipid and serum leptin concentration of participants were measured and determined by physical examination and laboratory detection in 2014 and 2017. The differences in serum leptin levels between the new hypertensive and non-hypertensive people were compared after three years. The relationship between serum leptin levels and hypertension was analyzed by Logistic regression.
In 2014 and 2017, concentration of serum leptin in females was significantly higher than that in males, and the blood pressure in males was higher than that in females. At the end of follow-up, 26 new cases of hypertension were found. Serum leptin levels were higher in the female hypertensive group than in the non-hypertensive group(P=0. 0289), whereas there was no statistical difference in males(P>0. 01). Regardless of gender, serum leptin was significantly positively correlated with body mass index(BMI) and waist-to-height ratio(WHtR)(P<0. 0001), and also had correlation with blood pressure. However, after adjusting for BMI or WHtR, the correlation between serum leptin and blood pressure disappeared(P>0. 01). Logistic regression also showed the similar result.
Serum leptin is not directly related to blood pressure and hypertension, and the positive correlation between them may be explained largely by BMI and WHtR.
探讨不同性别血清瘦素浓度与血压及高血压之间的关联。
2014年从浙江省随机选取343名年龄在30至65岁之间的非高血压居民。通过2014年和2017年的体格检查和实验室检测，测量并确定参与者的身高、体重、腰围、血压、血脂和血清瘦素浓度等参数。三年后比较新患高血压者与非高血压者血清瘦素水平的差异。采用Logistic回归分析血清瘦素水平与高血压的关系。
2014年和2017年，女性血清瘦素浓度显著高于男性，男性血压高于女性。随访结束时，发现26例新的高血压病例。女性高血压组血清瘦素水平高于非高血压组（P = 0.0289），而男性无统计学差异（P>0.01）。无论性别如何，血清瘦素与体重指数（BMI）和腰高比（WHtR）均呈显著正相关（P<0.0001），且与血压也有关联。然而，在调整BMI或WHtR后，血清瘦素与血压之间的相关性消失（P>0.01）。Logistic回归也显示了类似结果。
血清瘦素与血压及高血压无直接关系，它们之间的正相关可能主要由BMI和WHtR来解释。
