Hu Jianxiang, He Yuna, Zhuo Qin, Xia Juan, Yang Linli, Zhang Ronghua, Huang Lichun
The Key Laboratory of Trace Element Nutrition NHFPC, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Wei Sheng Yan Jiu. 2017 Mar;46(2):173-178.
To investigate the association between body mass index(BMI), waist-to-height ratio(WHtR) and dietary fat with serum leptin concentration.
A three-day 24-h dietary recall method was conducted on 513 participants aged30-65 years who were randomly selected from Zhejiang Province in 2014 to investigate usual fat intake. In addition, parameters including height, weight, waist and serum leptinconcentration of participants were measured and determined by physical examination and laboratory detection.
Concentration of serum leptin in women was significantly higher than that in men( P< 0. 001). Both BMI and WHtR were positively correlated with serum leptin level( men: r=0. 488 and 0. 576, women: r =0. 453 and 0. 333, P<0. 0001), but only correlation of WHtR that men(r=0. 354, P<0. 0001) and BMI in women(r=0. 321, P< 0. 0001) remained when BMI and WHtR were controlled respectively. Standardized partial regression coefficient of WHtR(β =0. 27) was higher than that of BMI(β=0. 21) in men while in women the coefficient of BMI(β=0. 26)was higher than that of WHtR(β = 0. 20). Serum leptin level was negatively correlated with total energy, total fat and MUFA in men(P<0. 05), but the correlation between total energy and leptin was disappeared when WHtR was controlled for. Serum leptin level was positively correlated with the proportion of PUFA from total energy and(PUFA +MUFA) ∶ SFA in women(P<0. 05), while only the correlation between the proportion of PUFA from total energy and leptin remained when BMI was controlled for.
Obesity degree was gender-specifically positively correlated with serum leptin level, which indicated different obesity indicators should be used for men and women when analyzing serum leptin. Serum leptin was negatively correlated with total fat and MUFA in men, while positively correlated with the proportion of PUFA from total energy in women.
探讨体重指数（BMI）、腰高比（WHtR）和膳食脂肪与血清瘦素浓度之间的关联。
2014年从浙江省随机选取513名30 - 65岁的参与者，采用三日24小时膳食回顾法调查其日常脂肪摄入量。此外，通过体格检查和实验室检测测量并确定参与者的身高、体重、腰围和血清瘦素浓度等参数。
女性血清瘦素浓度显著高于男性（P < 0.001）。BMI和WHtR均与血清瘦素水平呈正相关（男性：r = 0.488和0.576，女性：r = 0.453和0.333，P < 0.0001），但在分别控制BMI和WHtR后，仅男性的WHtR（r = 0.354，P < 0.0001）和女性的BMI（r = 0.321，P < 0.0001）仍保持相关性。男性中WHtR的标准化偏回归系数（β = 0.27）高于BMI（β = 0.21），而女性中BMI的系数（β = 0.26）高于WHtR（β = 0.20）。男性血清瘦素水平与总能量、总脂肪和单不饱和脂肪酸（MUFA）呈负相关（P < 0.05），但在控制WHtR后，总能量与瘦素之间的相关性消失。女性血清瘦素水平与总能量中多不饱和脂肪酸（PUFA）的比例以及（PUFA + MUFA）∶饱和脂肪酸（SFA）呈正相关（P < 0.05），而在控制BMI后，仅总能量中PUFA的比例与瘦素之间的相关性仍存在。
肥胖程度与血清瘦素水平存在性别特异性正相关，这表明在分析血清瘦素时，男性和女性应使用不同的肥胖指标。男性血清瘦素与总脂肪和MUFA呈负相关，而女性血清瘦素与总能量中PUFA的比例呈正相关。
