Mora B, Douard H, Colle J P, Ohayon J, Choussat A, Broustet J P
Arch Mal Coeur Vaiss. 1987 Mar;80(3):310-7.
The authors present 6 personal cases of complete obstruction of the left main stem coronary artery and review the main epidemiological, clinical, ergometric, haemodynamic, angiographic and therapeutic data concerning this condition which is uncommon (0.66% of patients who underwent coronary angiography for angina in this series). This series had a number of special features. Clinical symptoms were moderate, consisting of exercise-induced aggravated angina, except in one patient with a history of anterior infarction complicated by regressive initial heart failure with residual angina. For this reason, all patients were able to perform a standard exercise-test on an ergometric bicycle without any problem. As the exercise test revealed major abnormalities, extreme precautions were observed when coronary angiography was performed, but no incident occurred in any of the 6 patients. Haemodynamic data were normal in 4 cases and altered in 2 cases. The important role played by collateral circulation must be stressed; it is probably under evaluated at arteriography. The absence of lesion of the right coronary artery is thought to facilitate the development of a collateral vascular network. Five patients were operated upon, made an uneventful recovery and were followed up for 19, 42, 17, 5 and 2 months respectively: all were symptom-free under medical treatment. In 3 out of these 5 patients who underwent a post-operative exercise-test all parameters showed excellent results; however, the 4th patient proved unadaptable to exercise, and ECG showed persistent ischaemia due to a very poor distal coronary bed; in the 5th patient, under diltiazem, the results on ischaemia and on the circulatory signs of heart failure were very good.(ABSTRACT TRUNCATED AT 250 WORDS)
作者介绍了6例左主干冠状动脉完全阻塞的个人病例,并回顾了有关这种不常见病症(本系列中因心绞痛接受冠状动脉造影的患者的0.66%)的主要流行病学、临床、运动测量、血流动力学、血管造影和治疗数据。本系列有一些特殊特征。临床症状较轻,表现为运动诱发的心绞痛加重,除了一名有前壁心肌梗死病史并伴有进行性初始心力衰竭且残留心绞痛的患者。因此,所有患者都能毫无问题地在测力计自行车上进行标准运动试验。由于运动试验显示出重大异常,在进行冠状动脉造影时采取了极端预防措施,但6例患者中无一发生意外。血流动力学数据4例正常,2例改变。必须强调侧支循环所起的重要作用;在动脉造影中它可能未得到充分评估。右冠状动脉无病变被认为有助于侧支血管网络的形成。5例患者接受了手术,恢复顺利,分别随访了19、42、17、5和2个月:所有患者在药物治疗下均无症状。在这5例接受术后运动试验的患者中,3例所有参数结果都非常好;然而,第4例患者被证明无法适应运动,心电图显示由于远端冠状动脉床非常差而持续缺血;在第5例患者中,在使用地尔硫䓬的情况下,缺血和心力衰竭循环体征的结果非常好。(摘要截短至250字)