以社区生态学为框架的人类微生物组研究。
Community ecology as a framework for human microbiome research.
机构信息
Department of Pediatrics and Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, USA.
Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Nat Med. 2019 Jun;25(6):884-889. doi: 10.1038/s41591-019-0464-9. Epub 2019 May 27.
Abstract
The field of human microbiome research has revealed the intimate co-association of humans with diverse communities of microbes in various habitats in the human body, and the necessity of these microbes for the maintenance of human health. Microbial heterogeneity between humans and across spatial and temporal gradients requires multidimensional datasets and a unifying set of theories and statistical tools to analyze the human microbiome and fully realize the potential of this field. Here we consider the utility of community ecology as a framework for the interrogation and interpretation of the human microbiome.
摘要
人类微生物组研究领域揭示了人类与人体各种生境中多样微生物群落的密切共生关系，以及这些微生物对人类健康的维持的必要性。人类之间以及跨空间和时间梯度的微生物异质性需要多维数据集和一套统一的理论和统计工具来分析人类微生物组，并充分挖掘该领域的潜力。在这里，我们考虑将群落生态学作为一种框架，用于探究和解释人类微生物组。
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