Qingdao University, Qingdao, 266071, Shandong, China.
Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, 272029, Jining, Shandong, China.
Sci Rep. 2019 May 27;9(1):7879. doi: 10.1038/s41598-019-44299-9.
Blood pressure (BP), especially systolic BP (SBP), is higher in adult growth hormone deficiency (AGHD) patients than in normal controls. Additionally, obesity is a known risk factor for hypertension, and growth hormone deficiency (GHD) is an important cause of short stature. For children with GHD, attention has been directed solely towards height. Few studies have assessed its potential impact on BP. Here, we investigated the effect of body mass index standard deviation score (BMISDS) on BP in children with short stature. This study included 736 children with short stature divided into two groups based on peak growth hormone (GH) level in GH provocation tests [severe GHD (SGHD) group = 212 children; non-SGHD group = 524 children]. We found that SBP was significantly higher in the SGHD group than in the non-SGHD group (p = 0.045). Additionally, there was a significant positive association between BMISDS and SBP in the SGHD group (β = 3.12, 95% CI: 1.40-4.84, p < 0.001), but no association between these variables was observed in the non-SGHD group. Thus, SGHD patients had a higher SBP than non-SGHD patients. BMISDS is a significant factor for higher SBP in SGHD patients but not in non-SGHD patients.
血压（BP），尤其是收缩压（SBP），在成人生长激素缺乏症（AGHD）患者中高于正常对照组。此外，肥胖是高血压的已知危险因素，而生长激素缺乏症（GHD）是身材矮小的重要原因。对于患有 GHD 的儿童，人们仅关注身高。很少有研究评估其对 BP 的潜在影响。在这里，我们研究了体重指数标准差评分（BMISDS）对矮小儿童 BP 的影响。本研究纳入了 736 名身材矮小的儿童，根据 GH 激发试验中的峰值生长激素（GH）水平将其分为两组[严重 GHD（SGHD）组=212 名儿童；非 SGHD 组=524 名儿童]。我们发现，SGHD 组的 SBP 明显高于非 SGHD 组（p=0.045）。此外，SGHD 组的 BMISDS 与 SBP 呈显著正相关（β=3.12，95%CI：1.40-4.84，p<0.001），而非 SGHD 组则无相关性。因此，SGHD 患者的 SBP 高于非 SGHD 患者。BMISDS 是 SGHD 患者 SBP 升高的重要因素，但对非 SGHD 患者则无影响。
