Biological Resource Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Front Immunol. 2019 May 10;10:964. doi: 10.3389/fimmu.2019.00964. eCollection 2019.
Human leukocyte antigens (HLAs) play various critical roles in both innate and adaptive immunity through processes such as presenting antigens to T cells and serving as ligands for receptors expressed on natural killer (NK) cells. Among the HLA class I family, the clinical significance and biological function of HLA-F have been the least investigated and have remained elusive for a long period of time. Previous studies have revealed that HLA-F expression might be involved in various physiological and pathological processes, such as pregnancy, viral infection, cancer, transplantation, and autoimmune diseases. However, recent data have shown that, akin to other HLA family members, HLA-F molecules can interact with both activating and inhibitory receptors on immune cells, such as NK cells, and can present a diverse panel of peptides. These important findings pave new avenues for investigations regarding the functions of HLA-F as an important immune regulatory molecule. In the present review, we summarize the studies on the role of HLA-F in immune modulation, with a special emphasis placed on the roles of HLA-F and KIR3DS1 interactions in viral infection.
人类白细胞抗原 (HLA) 通过向 T 细胞呈递抗原和作为自然杀伤 (NK) 细胞表达的受体配体等过程，在固有和适应性免疫中发挥各种关键作用。在 HLA Ⅰ类家族中，HLA-F 的临床意义和生物学功能研究最少，长期以来一直难以捉摸。先前的研究表明，HLA-F 的表达可能参与多种生理和病理过程，如妊娠、病毒感染、癌症、移植和自身免疫性疾病。然而，最近的数据表明，与其他 HLA 家族成员一样，HLA-F 分子可以与 NK 细胞等免疫细胞上的激活和抑制受体相互作用，并呈现出多样化的肽谱。这些重要发现为研究 HLA-F 作为重要免疫调节分子的功能开辟了新的途径。在本综述中，我们总结了 HLA-F 在免疫调节中的作用研究，特别强调了 HLA-F 和 KIR3DS1 相互作用在病毒感染中的作用。
