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Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants.

作者信息

Geller Frank, Wu Xiaoping, Lammi Vilma, Abner Erik, Valliere Jesse Tyler, Nastou Katerina, Rasmussen Morten, Andersson Niklas Worm, Quinn Liam, Aagaard Bitten, Banasik Karina, Bliddal Sofie, Boding Lasse, Brunak Søren, Brøns Nanna, Bybjerg-Grauholm Jonas, Christoffersen Lea Arregui Nordahl, Didriksen Maria, Dinh Khoa Manh, Erikstrup Christian, Feldt-Rasmussen Ulla, Grønbæk Kirsten, Kaspersen Kathrine Agergård, Mikkelsen Christina, Nielsen Claus Henrik, Nielsen Henriette Svarre, Nielsen Susanne Dam, Nissen Janna, Sequeros Celia Burgos, Tommerup Niels, Ullum Henrik, Spiliopoulos Lampros, Bager Peter, Hviid Anders, Sørensen Erik, Pedersen Ole Birger, Lane Jacqueline M, Lassaunière Ria, Ollila Hanna M, Ostrowski Sisse Rye, Feenstra Bjarke

机构信息

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

出版信息

medRxiv. 2024 Nov 22:2024.11.21.24317689. doi: 10.1101/2024.11.21.24317689.

DOI:10.1101/2024.11.21.24317689
PMID:39606378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11601703/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/170e/11601703/724c38f9cde4/nihpp-2024.11.21.24317689v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/170e/11601703/060397b5f552/nihpp-2024.11.21.24317689v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/170e/11601703/724c38f9cde4/nihpp-2024.11.21.24317689v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/170e/11601703/060397b5f552/nihpp-2024.11.21.24317689v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/170e/11601703/724c38f9cde4/nihpp-2024.11.21.24317689v1-f0002.jpg

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本文引用的文献

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Nat Commun. 2024 Oct 9;15(1):8739. doi: 10.1038/s41467-024-52890-6.
2
Genetic risk factors for COVID-19 and influenza are largely distinct.COVID-19 和流感的遗传风险因素在很大程度上是不同的。
Nat Genet. 2024 Aug;56(8):1592-1596. doi: 10.1038/s41588-024-01844-1. Epub 2024 Aug 5.
3
Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity.
SARS-CoV-2 刺突蛋白多碱性裂解位点的连续糖基化调节病毒活性。
Nat Commun. 2024 May 16;15(1):4162. doi: 10.1038/s41467-024-48503-x.
4
Enhanced Surface Accessibility of SARS-CoV-2 Omicron Spike Protein Due to an Altered Glycosylation Profile.由于糖基化谱的改变，增强了 SARS-CoV-2 奥密克戎刺突蛋白的表面可及性。
ACS Infect Dis. 2024 Jun 14;10(6):2032-2046. doi: 10.1021/acsinfecdis.4c00015. Epub 2024 May 10.
5
Cohort profile: EFTER-COVID - a Danish nationwide cohort for assessing the long-term health effects of the COVID-19 pandemic.队列资料简介：EFTER-COVID - 一个丹麦全国性队列，用于评估 COVID-19 大流行的长期健康影响。
BMJ Open. 2024 May 6;14(5):e087799. doi: 10.1136/bmjopen-2024-087799.
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Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.对 100 多万欧洲血统个体进行全基因组分析，可提高血压特征的多基因风险评分。
Nat Genet. 2024 May;56(5):778-791. doi: 10.1038/s41588-024-01714-w. Epub 2024 Apr 30.
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