Department of Obstetrics & Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, 833 Chestnut Street, Suite 301, Philadelphia, PA, 19107, USA.
Department of Gynecology and Obstetrics, Emory University School of Medicine, 550 Peachtree Street, Suite 1800, Atlanta, GA, 30308, USA.
J Assist Reprod Genet. 2019 Jul;36(7):1449-1456. doi: 10.1007/s10815-019-01490-1. Epub 2019 May 27.
To explore associations between infertility treatment and hypertensive disorders of pregnancy.
We collated multi-year as well as multi-state data from a national representative survey examining the association between self-reported infertility treatment (i.e., medication, intrauterine insemination, or assisted reproductive technology) and hypertensive disorders of pregnancy (i.e., high blood pressure, pregnancy-induced hypertension (PIH), preeclampsia, and toxemia). Data were analyzed using logistic regression. A total of 21,884 women in the United States (U.S.), from the Centers for Disease Control and Prevention's (CDC) Pregnancy Risk Assessment Monitoring System (PRAMS) survey (2009-2015), participated in the study.
In our analysis, 12.91% women reported a history of infertility treatment and 15.19% reported a history of hypertensive disorder of pregnancy. Compared with women who had never had infertility treatment, women who reported infertility treatment had 1.18 (adjusted OR, 95% confidence interval (CI) 1.05, 1.33) higher odds of reporting hypertensive disorder of pregnancy. Neither types of infertility treatment nor proximity of treatment to pregnancy were independently associated with hypertensive disorder of pregnancy.
Our results suggest that among U.S. women, the treatment of infertility may be associated with hypertension disorder of pregnancy regardless of type of treatment.
探讨不孕治疗与妊娠高血压疾病之间的关联。
我们从一项全国代表性调查中整理了多年和多州的数据，该调查研究了自我报告的不孕治疗（即药物治疗、宫腔内人工授精或辅助生殖技术）与妊娠高血压疾病（即高血压、妊娠高血压（PIH）、子痫前期和毒血症）之间的关联。使用逻辑回归分析数据。来自美国疾病控制与预防中心（CDC）妊娠风险评估监测系统（PRAMS）调查（2009-2015 年）的 21884 名美国妇女参与了这项研究。
在我们的分析中，12.91%的妇女报告有不孕治疗史，15.19%的妇女报告有妊娠高血压疾病史。与从未接受过不孕治疗的妇女相比，报告有不孕治疗史的妇女报告妊娠高血压疾病的几率高 1.18 倍（调整后的 OR，95%置信区间（CI）1.05，1.33）。不孕治疗的类型和治疗与妊娠的时间间隔均与妊娠高血压疾病无关。
我们的研究结果表明，在美国妇女中，不孕治疗可能与高血压疾病有关，无论治疗类型如何。
