Thomopoulos Costas, Salamalekis George, Kintis Konstantinos, Andrianopoulou Iliana, Michalopoulou Helena, Skalis George, Archontakis Stefanos, Argyri Ourania, Tsioufis Costas, Makris Thomas K, Salamalekis Emmanuel
Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
Department of Obstetrics and Gynecology, Gaia Maternity Hospital, Athens, Greece.
J Clin Hypertens (Greenwich). 2017 Feb;19(2):173-183. doi: 10.1111/jch.12945. Epub 2016 Nov 7.
The extent of the increased risk of pregnancy hypertensive disorders following assisted reproductive technology (ART) was investigated. PubMed and the Cochrane Collaboration Library were used as data sources to identify and select longitudinal cohorts comparing pregnancies following ART with spontaneously conceived pregnancies, between 1978 and June 2016. Risk ratios and 95% confidence intervals (CIs) of three outcomes, ie, gestational hypertension (GH), preeclampsia (PE), and their sum (PHD), were calculated. Stratification of results by gestation order (singletons and nonsingletons) was pursued, but a separate "all orders" mixed stratification was considered. Sixty-six longitudinal studies (7 038 029 pregnancies; 203 375 following any ART) were eligible. All outcomes independent of gestation order ("all orders") were increased following any invasive ART: GH (+79% [95% CI, 24%-157%]) and PE (+75% [95% CI, 50%-103%]) to a greater extent, with smaller increases in PHD (+54% [95% CI, 39%-70%]). The risk of PHD following ART steadily increased independent of gestation order.
研究了辅助生殖技术（ART）后妊娠高血压疾病风险增加的程度。使用PubMed和Cochrane协作图书馆作为数据源，以识别和选择1978年至2016年6月期间将ART后妊娠与自然受孕妊娠进行比较的纵向队列。计算了三种结局的风险比和95%置信区间（CI），即妊娠期高血压（GH）、先兆子痫（PE）及其总和（PHD）。按妊娠顺序（单胎和多胎）对结果进行分层，但考虑了单独的“所有顺序”混合分层。66项纵向研究（7038029例妊娠；任何ART后203375例）符合条件。任何侵入性ART后，所有与妊娠顺序无关的结局（“所有顺序”）均增加：GH（+79%[95%CI，24%-157%]）和PE（+75%[95%CI，50%-103%]）增加幅度更大，PHD增加幅度较小（+54%[95%CI，39%-70%]）。ART后PHD的风险稳步增加，与妊娠顺序无关。
