Ermert Philipp, Luther Anatol, Zbinden Peter, Obrecht Daniel
Polyphor Ltd., Allschwil, Switzerland.
Methods Mol Biol. 2019;2001:147-202. doi: 10.1007/978-1-4939-9504-2_9.
This review describes a selection of macrocyclic natural products and structurally modified analogs containing peptidic and non-peptidic elements as structural features that potentially modulate cellular permeability. Examples range from exclusively peptidic structures like cyclosporin A or phepropeptins to compounds with mostly non-peptidic character, such as telomestatin or largazole. Furthermore, semisynthetic approaches and synthesis platforms to generate general and focused libraries of compounds at the interface of cyclic peptides and non-peptidic macrocycles are discussed.
本综述介绍了一系列大环天然产物及其结构修饰类似物，这些化合物含有肽类和非肽类元素作为可能调节细胞通透性的结构特征。例子涵盖了完全为肽类结构的化合物，如环孢菌素A或苯丙肽菌素，到主要具有非肽类特征的化合物，如端粒抑素或拉戈唑。此外，还讨论了在环肽和非肽大环化合物界面生成通用和特定化合物库的半合成方法及合成平台。
