School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
School of Traditional Chinese Materia Medica, Shenyang Parmaceutical University, Shenyang, China.
Nat Prod Res. 2020 Nov;34(22):3212-3218. doi: 10.1080/14786419.2018.1557172. Epub 2019 May 28.
A new triterpenoid saponin (), 3--[-D-glucopyranosyl(1→6)]-(2-angeloyl)--D-glucopyranosyl-28---D-glucopyranosyl(1→6)[-L-rhamnopyranosyl(1→2)--D-glucopyranosyl]-21--acetyl-16-deoxybarringtogenol C, together with four known saponins () were isolated from the husks of . Their structures were characterized by HR-ESI-MS, 1D-NMR, 2D-NMR spectra and chemical methods. Compound exhibited excellent neuroprotection on PC12 cells injury induced by Aβ at the doses of 150 μmol/L and 200 μmol/L. The cell viabilities were (76.18 ± 2.09) % and (76.02 ± 3.20) %, respectively.[Formula: see text].
从巴戟天的种皮中分离得到了一种新的三萜皂苷（），命名为 3--[-D-吡喃葡萄糖基(1→6)]-(2-当归酰基)--D-吡喃葡萄糖基-28---D-吡喃葡萄糖基(1→6)[-L-鼠李吡喃糖基(1→2)--D-吡喃葡萄糖基]-21--乙酰基-16-去氧巴尔他汀 C，此外还分离得到了四种已知的皂苷（）。通过高分辨电喷雾质谱（HR-ESI-MS）、一维核磁共振（1D-NMR）、二维核磁共振（2D-NMR）谱和化学方法对它们的结构进行了表征。化合物在 150 μmol/L 和 200 μmol/L 剂量下对 Aβ诱导的 PC12 细胞损伤表现出优异的神经保护作用，细胞活力分别为（76.18 ± 2.09）%和（76.02 ± 3.20）%。
