从布氏甜龙眼中壳提取的一种新的齐墩果烷型五环三萜皂苷及其对 Aβ诱导的 PC12 细胞损伤的神经保护作用。
A new oleanane type pentacyclic triterpenoid saponin from the husks of bunge and its neuroprotection on PC12 cells injury induced by Aβ.
机构信息
School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
School of Traditional Chinese Materia Medica, Shenyang Parmaceutical University, Shenyang, China.
出版信息
Nat Prod Res. 2020 Nov;34(22):3212-3218. doi: 10.1080/14786419.2018.1557172. Epub 2019 May 28.
A new triterpenoid saponin (), 3--[-D-glucopyranosyl(1→6)]-(2-angeloyl)--D-glucopyranosyl-28---D-glucopyranosyl(1→6)[-L-rhamnopyranosyl(1→2)--D-glucopyranosyl]-21--acetyl-16-deoxybarringtogenol C, together with four known saponins () were isolated from the husks of . Their structures were characterized by HR-ESI-MS, 1D-NMR, 2D-NMR spectra and chemical methods. Compound exhibited excellent neuroprotection on PC12 cells injury induced by Aβ at the doses of 150 μmol/L and 200 μmol/L. The cell viabilities were (76.18 ± 2.09) % and (76.02 ± 3.20) %, respectively.[Formula: see text].
从巴戟天的种皮中分离得到了一种新的三萜皂苷（），命名为 3--[-D-吡喃葡萄糖基(1→6)]-(2-当归酰基)--D-吡喃葡萄糖基-28---D-吡喃葡萄糖基(1→6)[-L-鼠李吡喃糖基(1→2)--D-吡喃葡萄糖基]-21--乙酰基-16-去氧巴尔他汀 C，此外还分离得到了四种已知的皂苷（）。通过高分辨电喷雾质谱（HR-ESI-MS）、一维核磁共振（1D-NMR）、二维核磁共振（2D-NMR）谱和化学方法对它们的结构进行了表征。化合物在 150 μmol/L 和 200 μmol/L 剂量下对 Aβ诱导的 PC12 细胞损伤表现出优异的神经保护作用，细胞活力分别为（76.18 ± 2.09）%和（76.02 ± 3.20）%。
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