Project for Immunogenomics, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Jpn J Clin Oncol. 2019 Jul 1;49(7):596-603. doi: 10.1093/jjco/hyz073.
The advancement of cancer genomics research due to the development of next generation sequencing technologies is going to bring the promise of cancer precision medicine, in turn revolutionizing cancer detection and treatment. In this review, we will discuss the possible road map for implementation of cancer precision medicine into the clinical practice by mainly focusing on the role of liquid biopsy, particularly circulating tumor DNA, as a potential tool for cancer screening, selection of an appropriate drug(s), surveillance of minimal residual diseases, and early detection of recurrence. We will also review the current status of genome-driven oncology and emerging field of immunotherapies that could be provided to patients to improve their clinical outcome and quality of life. Lastly, we will discuss the usefulness of artificial intelligence that facilitate complex data integration in our health care/medical care system.
由于下一代测序技术的发展,癌症基因组学研究取得了进展,这将带来癌症精准医学的希望,从而彻底改变癌症的检测和治疗方式。在这篇综述中,我们将主要讨论通过液体活检(特别是循环肿瘤 DNA)将癌症精准医学应用于临床实践的可能路线图,作为癌症筛查、选择合适药物、监测微小残留疾病和早期检测复发的潜在工具。我们还将回顾当前基于基因组的肿瘤学和新兴的免疫疗法领域,这些领域可以为患者提供服务,以改善他们的临床结果和生活质量。最后,我们将讨论人工智能在促进我们的医疗保健系统中复杂数据集成方面的作用。