Department of Applied Sciences, National Textile University, Faisalabad, Pakistan.
Department of Chemistry, University of Agriculture, Faisalabad, Pakistan.
Biotechnol Prog. 2019 Sep;35(5):e2855. doi: 10.1002/btpr.2855. Epub 2019 Jun 21.
Poly(hydroxybutyrate) (PHB) has become an attractive biomaterial in research and development for past few years. It is natural bio-based aliphatic polyester produced by many types of bacteria. Due to its biodegradable, biocompatible, and eco-friendly nature, PHB can be used in line with bioactive species. However, high production cost, thermal instability, and poor mechanical properties limit its desirable applications. So there is need to incorporate PHB with other materials or biopolymers for the development of some novel PHB based biocomposites for value addition. Many attempts have been employed to incorporate PHB with other biomaterials (or biopolymers) to develop sustainable biocomposites. In this review, some recent developments in the synthesis of PHB based biocomposites and their biomedical, packaging and tissue engineering applications have been focused. The development of biodegradable PHB based biocomposites with improved mechanical properties could be used to overcome its native limitations hence to open new possibilities for industrial applications.
聚羟基丁酸酯 (PHB) 在过去几年中已成为研究和开发中极具吸引力的生物材料。它是由许多类型的细菌产生的天然生物基脂肪族聚酯。由于其可生物降解、生物相容性和环保特性，PHB 可用于符合生物活性的物质。然而，高生产成本、热不稳定性和较差的机械性能限制了其理想的应用。因此，需要将 PHB 与其他材料或生物聚合物结合，以开发一些具有附加值的新型 PHB 基生物复合材料。已经尝试了许多方法将 PHB 与其他生物材料（或生物聚合物）结合，以开发可持续的生物复合材料。在这篇综述中，重点介绍了 PHB 基生物复合材料的合成及其在生物医学、包装和组织工程应用方面的一些最新进展。开发具有改善机械性能的可生物降解 PHB 基生物复合材料，可以克服其固有局限性，从而为工业应用开辟新的可能性。
