Bioengineering Laboratory, Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, 1 Hoppin Street, CORO West Suite 404, Providence, RI 02903, USA.
Bioengineering Laboratory, Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, 1 Hoppin Street, CORO West Suite 404, Providence, RI 02903, USA.
Osteoarthritis Cartilage. 2019 Sep;27(9):1315-1323. doi: 10.1016/j.joca.2019.05.008. Epub 2019 May 25.
Osteophyte formation is a critical part of the degeneration of a joint with osteoarthritis (OA). While often qualitatively described, few studies have succeeded in quantifying osteophyte growth over time. Using computed tomography (CT) image data from a longitudinal, observational study of thumb carpometacarpal (CMC) OA, our aim was to quantify osteophyte growth volume and location over a three-year period in men and women.
Ninety patients with early thumb OA were recruited and assessed at baseline, 1.5 years, and 3 years with CT imaging. Osteophyte volume and location on the trapezium and first metacarpal were determined using a library of 46 healthy subjects as a nonarthritic reference database.
There was a significant increase in osteophyte volume for women and men over the three-year follow-up in the trapezium (86.8 mm-120.5 mm and 165.1 mm-235.3 mm, means respectively) and in the proximal metacarpal (63 mm-80.4 mm, and 115.8 mm-161.7 mm, respectively). The location of osteophyte initiation and growth was consistent across subjects and was located in non-opposing regions on the trapezium and first metacarpal. Osteophyte growth occurred about the radial and ulnar margins of the trapezial facet, while on the proximal metacarpal, growth occurred principally about the volar and dorsal margins of the facet.
Osteophyte growth occurred in early thumb osteoarthritis over three years. Growth was localized in specific, non-opposing regions on the trapezium and metacarpal, raising intriguing questions about the triggers for their formation, whether the mechanisms are mechanical, biological or a combination of both.
骨赘形成是骨关节炎（OA）关节退变的关键部分。虽然通常定性描述，但很少有研究成功地定量评估骨赘随时间的生长。本研究使用来自拇指腕掌（CMC）OA 纵向观察研究的 CT 图像数据，旨在定量评估男性和女性三年内骨赘生长体积和位置。
招募了 90 例早期拇指 OA 患者，分别在基线、1.5 年和 3 年时进行 CT 成像评估。使用 46 例健康受试者的资料库作为非关节炎参考数据库，确定骨赘在舟骨和第一掌骨上的体积和位置。
女性和男性在三年内随访中，舟骨的骨赘体积明显增加（分别为 86.8mm-120.5mm 和 165.1mm-235.3mm），第一掌骨近端的骨赘体积也明显增加（分别为 63mm-80.4mm 和 115.8mm-161.7mm）。骨赘起始和生长的位置在不同患者之间是一致的，位于舟骨和第一掌骨的非对向区域。骨赘生长发生在舟状骨关节面的桡侧和尺侧边缘，而在掌骨近端，生长主要发生在关节面的掌侧和背侧边缘。
在三年内，早期拇指骨关节炎发生了骨赘生长。生长局限于舟骨和掌骨的特定非对向区域，这引发了关于其形成触发因素的有趣问题，无论是机械的、生物学的还是两者结合的机制。
