ribotype 017 - characterization, evolution and epidemiology of the dominant strain in Asia.

ribotype (RT) 017 is an important toxigenic RT which, due to a deletion in the repetitive region of the gene, only produces functional toxin B. Strains belonging to this RT were initially dismissed as nonpathogenic and circulated largely undetected for almost two decades until they rose to prominence following a series of outbreaks in the early 2000s. Despite lacking a functional toxin A, RT 017 strains have been shown subsequently to be capable of causing disease as severe as that caused by strains producing both toxins A and B. While RT 017 strains can be found in almost every continent today, epidemiological studies suggest that the RT is endemic in Asia and that the global spread of this MLST clade 4 lineage member is a relatively recent event. RT 017 transmission appears to be mostly from human to human with only a handful of reports of isolations from animals. An important feature of RT 017 strains is their resistance to several antimicrobials and this has been documented as a possible factor driving multiple outbreaks in different parts of the world. This review summarizes what is currently known regarding the emergence and evolution of strains belonging to RT 017 as well as features that have allowed it to become an RT of global importance.