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葡萄牙产艰难梭菌 017 型亚单位的亚胺培南耐药性。

Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal.

出版信息

Emerg Infect Dis. 2018 Apr;24(4):741-745. doi: 10.3201/eid2404.170095.

DOI:10.3201/eid2404.170095
PMID:29553322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5875251/
Abstract

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.

摘要

我们描述了葡萄牙产的耐亚胺培南和易感性的艰难梭菌 017 型临床分离株。所有的 017 型分离株都携带额外的青霉素结合蛋白基因 pbp5，而耐亚胺培南的分离株在 pbp1 和 pbp3 的转肽酶活性位点附近有额外的取代。这些克隆可以传播并导致亚胺培南耐药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b6/5875251/855d71e86736/17-0095-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b6/5875251/aa20747f40a6/17-0095-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b6/5875251/855d71e86736/17-0095-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b6/5875251/aa20747f40a6/17-0095-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6b6/5875251/855d71e86736/17-0095-F2.jpg

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