Department of Dermatology, Harvard Medical School and Clinical Laboratory for Epidemiology and Applied Research in Skin (CLEARS), Beth Israel Deaconess Medical Center, Boston, MA, USA.
Am J Clin Dermatol. 2019 Oct;20(5):625-638. doi: 10.1007/s40257-019-00439-5.
Patients with hidradenitis suppurativa (HS) are often undertreated and there are limited efficacious therapies available for treating this population. Biologics are an emerging therapeutic modality used in the management of many inflammatory conditions including HS. Implementation of biologics is typically reserved for moderate-to-severe cases or in those cases that are refractory to treatment. Though many biologics have been trialed for use in HS, only one biologic, adalimumab, is currently US FDA (Food and Drug Administration) approved for the treatment of moderate-to-severe HS. Limitations in the use of biologics for HS include the many scoring systems utilized in research studies and the relatively few well-designed, adequately powered clinical trials.
患有化脓性汗腺炎(HS)的患者往往治疗不足,而且可供治疗该人群的有效疗法有限。生物制剂是一种新兴的治疗方式,用于治疗许多炎症性疾病,包括 HS。生物制剂的应用通常保留给中重度病例,或对治疗有抵抗的病例。尽管有许多生物制剂已被尝试用于 HS 的治疗,但目前仅有一种生物制剂阿达木单抗(adalimumab)被美国食品药品监督管理局(FDA)批准用于治疗中重度 HS。HS 生物制剂使用受限的原因包括在研究中使用的许多评分系统,以及相对较少的精心设计、充分有力的临床试验。