Martorell A, Caballero A, González Lama Y, Jiménez-Gallo D, Lázaro Serrano M, Miranda J, Pascual J C, Salgado-Boquete L, Marín-Jiménez I
Servicio de Dermatología, Hospital de Manises, Valencia, España.
Servicio de Gastroenterología, Hospital General Universitario Gregorio Marañón, Madrid, España.
Actas Dermosifiliogr. 2016 Sep;107 Suppl 2:32-42. doi: 10.1016/S0001-7310(17)30007-8.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a high prevalence in the population. Treatment options are both medical and surgical. Medical treatment is based on the use of antibiotics, retinoids, and anti-inflammatory drugs, in which anti-TNFα agents (infliximab y adalimumab) play a central role in the treatment of moderate-to-severe HS and enjoy the highest level of scientific support. Currently, adalimumab is the only drug approved in the summary of product characteristics for the treatment of this disease. Due to the scarcity of clinical trials in HS, there is still no therapeutic guideline backed by solid evidence and the evidence for most drugs is low. However, early treatment in patients with HS would probably reduce the complications of this disease. This review analyses the distinct treatments used in this dermatological disease and provides a therapeutic algorithm with different treatment options.
化脓性汗腺炎(HS)是一种在人群中患病率较高的慢性炎症性疾病。治疗选择包括药物治疗和手术治疗。药物治疗基于使用抗生素、维甲酸和抗炎药物,其中抗TNFα药物(英夫利昔单抗和阿达木单抗)在中重度HS的治疗中发挥核心作用,且得到了最高水平的科学支持。目前,阿达木单抗是产品特性总结中唯一被批准用于治疗该疾病的药物。由于HS的临床试验较少,目前仍没有基于确凿证据的治疗指南,大多数药物的证据水平较低。然而,HS患者的早期治疗可能会减少该疾病的并发症。本综述分析了这种皮肤病所使用的不同治疗方法,并提供了具有不同治疗选择的治疗算法。