a Department of Clinical Biochemistry, Hvidovre University Hospital , Hvidovre , Denmark.
b Department of Clinical Medicine, University of Copenhagen , Copenhagen N , Denmark.
Scand J Clin Lab Invest. 2019 Sep;79(5):320-324. doi: 10.1080/00365513.2019.1622032. Epub 2019 May 29.
Hemoglobin A (HbA) is a long-term measure for glucose concentration in plasma. Since its introduction as a diabetes monitoring tool, and its more recent application as a diagnostic tool, the number of measurements of HbA have risen dramatically. However, HbA change is slow, so repeating measurements should not be done too often. We use a large, unfiltered dataset from 52,017 patients to determine the possible rate of change in HbA concentration. In our laboratory, the critical difference between HbA measurements is 8.5%. Our data show that a 1-unit HbA rise takes 4 weeks to occur, hence, at a HbA concentration around 50 mmol/mol Hgb, a critically increased HbA concentration cannot be determined until after 16 weeks. Conversely a critically lower HbA1c can manifest itself after 2 weeks, but after 7 weeks the dropping tendency stops. The amount of measurements that can be cancelled because they were taken sooner than 16 weeks is 23 percent.
血红蛋白 A（HbA）是血浆中葡萄糖浓度的长期衡量标准。自作为糖尿病监测工具引入以来，以及最近作为诊断工具的应用，HbA 的测量数量急剧增加。然而，HbA 的变化非常缓慢，因此不应过于频繁地重复测量。我们使用来自 52017 名患者的大型未过滤数据集来确定 HbA 浓度可能的变化率。在我们的实验室中，HbA 测量的临界差值为 8.5%。我们的数据表明，HbA 升高 1 个单位需要 4 周的时间，因此，在 HbA 浓度约为 50mmol/mol Hgb 时，在 16 周后才能确定临界升高的 HbA 浓度。相反，临界值较低的 HbA1c 在 2 周后就可以表现出来，但在 7 周后，下降趋势就会停止。可以因为测量时间早于 16 周而取消的测量数量为 23%。
