School of Electronics and Information Engineering, Tianjin Polytechnic University , Tianjin , China.
State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University , Tianjin , China.
Int J Radiat Biol. 2019 Sep;95(9):1319-1325. doi: 10.1080/09553002.2019.1625463. Epub 2019 Jun 13.
To study the different effects of single- and hybrid-frequency magnetic fields on long-term potentiation (LTP) in synaptic plasticity. Based on the online electromagnetic field stimulation system and field excitatory postsynaptic potentials (fEPSPs) recording system, we applied four different single- and hybrid-frequency magnetic fields with an intensity of 1 mT to the Schaffer collateral (CA1) pathway of rat hippocampal slices in vitro. The amplitude of fEPSPs decreased significantly under both single- and hybrid-frequency magnetic stimulation. Lower single-frequency magnetic stimulation on LTP had a greater regulating effect, while the regulating effect among four different hybrid-frequency extremely low-frequency electromagnetic fields (ELF-EMFs) stimulations on LTP showed no significant differences. Single-frequency magnetic stimulation produces more significant regulatory effects, and the lower the frequency, the more significant the regulatory effect. The effect of hybrid-frequency magnetic stimulation in each group was similar, and there was no significant difference between each group. The 15-Hz single-frequency magnetic stimulation group showed the most significant regulatory effect, but once it was mixed with other higher frequency magnetic stimulation, its regulation effect was significantly weakened.
研究单频和混合频率磁场对突触可塑性长时程增强（LTP）的不同影响。基于在线电磁场刺激系统和场兴奋性突触后电位（fEPSPs）记录系统，我们将四种不同强度为 1mT 的单频和混合频率磁场应用于体外大鼠海马脑片的 Schaffer 侧支（CA1）通路。在单频和混合频率磁场刺激下，fEPSPs 的振幅均显著降低。低频单频磁场刺激对 LTP 的调节作用更大，而四种不同混合频率极低频电磁场（ELF-EMFs）刺激对 LTP 的调节作用无显著差异。单频磁场刺激产生更显著的调节作用，频率越低，调节作用越显著。每组混合频率磁场刺激的效果相似，各组之间无显著差异。15Hz 单频磁场刺激组表现出最显著的调节作用，但一旦与其他更高频率的磁场刺激混合，其调节作用就会显著减弱。
