School of Life Sciences, Tiangong University, Tianjin, China.
Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai, China.
Int J Radiat Biol. 2023;99(3):439-445. doi: 10.1080/09553002.2022.2094022. Epub 2022 Jul 13.
Music therapy, like red-pink (soothing) music, is an important treatment for neurological disorders associated with learning and memory. Magnetic fields have been proved to have a similar regulating effect. However, the effect of magnetic fields with musical rhythm generated by the combination of the two has not been confirmed. This study aimed to investigate the regulation of magnetic stimulation with music rhythm on LTP (long-term potentiation) of Schaffer-CA1.
This article selected three sorts of music tracks in different frequencies (music track (1) , music track (2) , music track (3) ) and four sorts of pure sinusoidal tracks of four different harmonic frequency (music track (4) the frequency is 3500 Hz; music track (5) the frequency is 2500 Hz; music track (6) the frequency is 1500 Hz; music track (7) the frequency is 500 Hz). These music tracks are converted into analog signals by the external sound card and power amplifier and fed into a homemade coil that meets the demand for this frequency bandwidth. The coil can generate seven sorts of time-varying magnetic fields with musical rhythm with a mean intensity of about 2 mT. We used multi-electrode array (MEA) to record the LTP signals of Schaffer-CA1 synaptic induced by seven sorts of musical rhythmic magnetic fields and analyze the regulation of them.
The musical rhythmic magnetic fields generated by track 1 and track 2 have a remarkable enhancing effect on the amplitude of fEPSPs (field excitatory postsynaptic potentials) ( < .05), and these effects intensify with the increase of frequency. Nevertheless, there is no significant enhancing effect on LTP of the rhythmic magnetic field generated by track 3 ( > .05). The sinusoidal magnetic fields generated by track 4 and track 5 have an enhancing effect on the amplitude of fEPSPs ( < .05), and the enhancement is better than track 1 and track 2. The sinusoidal magnetic fields generated by track 6 and track 7 have an inhibiting effect ( < .05).
We found that the enhancing effect of musical rhythmic magnetic fields generated by track 1 was the most significant. The frequency of 1500 Hz could be a turning-point frequency in the regulation of magnetic field on LTP.
音乐疗法，如红-粉色（舒缓）音乐，是治疗与学习和记忆相关的神经障碍的重要方法。磁场已被证明具有类似的调节作用。然而，尚未证实两种方法相结合产生的具有音乐节奏的磁场的效果。本研究旨在探讨磁刺激与音乐节奏对 Schaffer-CA1 的 LTP（长时程增强）的调节作用。
本文选择了三种不同频率的音乐曲目（音乐曲目 1、音乐曲目 2、音乐曲目 3）和四种不同谐波频率的纯正弦音轨（音乐曲目 4 的频率为 3500 Hz；音乐曲目 5 的频率为 2500 Hz；音乐曲目 6 的频率为 1500 Hz；音乐曲目 7 的频率为 500 Hz）。这些音乐曲目通过外部声卡和功率放大器转换为模拟信号，并输入到满足此带宽要求的自制线圈中。该线圈可以产生七种具有音乐节奏的时变磁场，平均强度约为 2 mT。我们使用多电极阵列（MEA）记录七种音乐节奏磁场诱导的 Schaffer-CA1 突触的 LTP 信号，并分析其调节作用。
音轨 1 和音轨 2 产生的音乐节奏磁场对 fEPSPs（场兴奋性突触后电位）的幅度有显著的增强作用（ < .05），并且这种作用随着频率的增加而增强。然而，音轨 3 产生的节奏磁场对 LTP 没有显著的增强作用（ > .05）。音轨 4 和音轨 5 产生的正弦磁场对 fEPSPs 的幅度有增强作用（ < .05），并且增强效果优于音轨 1 和音轨 2。音轨 6 和音轨 7 产生的正弦磁场具有抑制作用（ < .05）。
我们发现音轨 1 产生的音乐节奏磁场的增强效果最为显著。1500 Hz 的频率可能是磁场对 LTP 调节的转折点频率。
