Meira Aimée Teixeira Dos Santos, Tanajura Davi, Viana Irineu Dos Santos
Universidade Estadual do Sudoeste da Bahia (UESB), Departamento de Ciências Naturais (DCN), Vitória da Conquista, BA, Brasil.
Arq Gastroenterol. 2019 May 20;56(1):51-54. doi: 10.1590/S0004-2803.201900000-16.
The gastroesophageal reflux disease (GERD) is the most common esophageal disease in medical practice, and it is suspected according to patients' symptoms. GERD can be classified in erosive esophagitis (EE) according to the presence of upper gastrointestinal endoscopy findings.
To evaluate endoscopic findings in patients with symptoms suggestive of GERD comparing epicemiological and risk factors.
Upper endoscopy reports were examined retrospectively from patients with symptoms of GERD such as heartburn, regurgitation, cough, throat clearing, globus and chest pain. EE was determined based on Los Angeles classification. Comparisons between risk factors in EE and non-EE groups were done with statistical analysis.
A total of 984 endoscopic reports were examined and 676 selected for analysis (281 with EE and 395 with non-EE form). Most were female 381 (56.36%) with a mean age of 44.01±15.40 years. Hiatal hernia was present in 47(6.96%) and smoking in 41(6.07%). Univariate logistic regression showed that male (OR=2.24, CI 95%, 1.63-3.06) and hiatal hernia (OR=4.52, CI 95%, 2.30-8.89) were independent predictors of erosions in the EE group. The presence of hiatal hernia (OR=12.04, CI 95%, 3.57-40.62), smoking (OR=8.46, CI 95%, 3.28-31.32) and aged patients (OR=8.01, CI 95%, 2.42-26.49) were also indicated as a risk factor for severe EE (grades C and D of Los Angeles).
Male gender and hiatal hernia were associated with EE. Aged patients, smoking and hiatal hernia were related to severe EE. It is suggested that the risk factors for EE and non-EE types are different. Cohort studies are necessary to identify the exact mechanisms involved in each disease form.
胃食管反流病（GERD）是医学实践中最常见的食管疾病，根据患者症状怀疑患有该病。根据上消化道内镜检查结果，GERD可分为糜烂性食管炎（EE）。
比较流行病学和危险因素，评估有GERD症状患者的内镜检查结果。
回顾性检查有烧心、反流、咳嗽、清嗓、咽部异物感和胸痛等GERD症状患者的上消化道内镜检查报告。EE根据洛杉矶分类法确定。对EE组和非EE组的危险因素进行统计学分析比较。
共检查984份内镜检查报告，选取676份进行分析（281份为EE型，395份为非EE型）。大多数为女性，共381例（56.36%），平均年龄44.01±15.40岁。47例（6.96%）存在食管裂孔疝，41例（6.07%）吸烟。单因素逻辑回归显示，男性（OR=2.24，9５%CI，1.63-3.06）和食管裂孔疝（OR=4.52，9５%CI，2.30-8.89）是EE组糜烂的独立预测因素。食管裂孔疝（OR=12.04，9５%CI，3.57-40.62）、吸烟（OR=8.46，9５%CI，3.28-31.32）和老年患者（OR=8.01，9５%CI，2.42-26.49）也被认为是重度EE（洛杉矶分级C和D级）的危险因素。
男性和食管裂孔疝与EE有关。老年患者、吸烟和食管裂孔疝与重度EE有关。提示EE型和非EE型的危险因素不同。有必要进行队列研究以确定每种疾病形式的确切发病机制。
