TFT Nano Center, Belgrade, Serbia.
Faculty of Pharmacy, University Business Academy in Novi Sad, Novi Sad, Serbia.
J Cosmet Dermatol. 2020 Feb;19(2):494-501. doi: 10.1111/jocd.12999. Epub 2019 May 29.
Fullerene water complex establishes the optimal order and function of biomolecules in natural, biophysical way by transducing the signal through water hydrogen bonds to biomolecules.
This paper considers the effects of the patented hyper-harmonized-hydroxylated fullerene water complex (3HFWC) on biophysical properties of the skin collagen molecules.
Optomagnetic imaging spectroscopy (OMIS) has been used for the analysis of the biophysical skin properties (diamagnetic/paramagnetic) after applying three groups of different cosmetic products. Tested cosmetic products were prepared by replacing the active ingredients with 3HFWC or with water in four commercial products. The original commercial creams and their vehiculums with water added served as control groups. Data were statistically analyzed using paired t test in R software.
t Test gave statistically significant results for all of the products with 3HFWC, while within the control group, only body lotion and hand cream did show statistically significant results (P < 0.05). Significant improvements in abundance and quality of collagen in the dermis were achieved with body lotion with 3HFWC (p /p ranged from 0.82 to 0.97). While body lotion vehiculum made collagen-water interaction more stable (p /p ranged from 0.3 to 0.55), hand cream with 3HFWC made it more dynamic (p /p ranged from 0.63 to 0.49). Body lotion vehiculum improved the compactness of the dermis (p /p ranged from 0.2 to 1.03), as well as commercial hand cream (p /p ranged from 0.28 to 0.85).
Compared to the control groups, cosmetic products with 3HFWC demonstrated positive effects on the biophysical properties of the skin. Increased paramagnetic properties are linked to more unpaired electrons, their faster movement, and, finally, better signal transduction. Thus, products with 3HFWC could enable faster regeneration of collagen and prompt skin reaction to the negative environmental influences.
富勒烯水合物通过水氢键将信号转导至生物分子，以自然的、生物物理的方式建立生物分子的最佳顺序和功能。
本文研究了专利超谐和羟基化富勒烯水合物（3HFWC）对皮肤胶原分子生物物理特性的影响。
采用光磁共振成像光谱（OMIS）分析了应用三组不同化妆品产品后皮肤生物物理特性（抗磁性/顺磁性）的变化。在四种商业产品中，用 3HFWC 或水替代活性成分来制备测试化妆品。原始商业乳膏及其加了水的载体作为对照组。使用 R 软件中的配对 t 检验对数据进行了统计学分析。
t 检验表明，所有含有 3HFWC 的产品均具有统计学意义，而在对照组中，只有身体乳液和手部乳液显示出统计学意义（P < 0.05）。含有 3HFWC 的身体乳液显著提高了真皮中胶原蛋白的丰度和质量（p /p 范围为 0.82 至 0.97）。而身体乳液载体使胶原蛋白-水相互作用更加稳定（p /p 范围为 0.3 至 0.55），手部乳液则使其更具动态性（p /p 范围为 0.63 至 0.49）。身体乳液载体提高了真皮的紧致度（p /p 范围为 0.2 至 1.03），商业手部乳液也是如此（p /p 范围为 0.28 至 0.85）。
与对照组相比，含有 3HFWC 的化妆品对皮肤的生物物理特性具有积极影响。顺磁性增加与更多的不成对电子有关，它们的运动速度更快，最终信号转导更好。因此，含有 3HFWC 的产品可以加速胶原蛋白的再生，并使皮肤对负面环境影响迅速做出反应。
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