Tsutsumi M, Sugisaki T, Makino T, Miyagi N, Nakatani K, Shiratori T, Takahashi S, Konishi Y
Jpn J Cancer Res. 1987 Jul;78(7):631-3.
The content of glutathione S-transferase placental form (GST-pi) was immunohistochemically analyzed in 100 cases of human stomach carcinoma of various histological types and compared with the content in the stomach mucosa of the human fetus, infant and adult. High levels of GST-pi content were demonstrated in all stomach carcinomas except for signet ring cell carcinomas. High levels were also present in surface mucous cells and glandular cells of the stomach from a fetus aged 18 weeks, whereas only the parietal cells of fundic glands in the adult stomach showed slight staining for GST-pi. These results indicate that the phenotypic expression of GST-pi in human stomach carcinoma is oncofetal in character.
采用免疫组织化学方法分析了100例不同组织学类型的人胃癌中谷胱甘肽S-转移酶胎盘型（GST-pi）的含量，并与人类胎儿、婴儿及成人胃黏膜中的含量进行比较。除印戒细胞癌外，所有胃癌中均显示出高水平的GST-pi含量。18周龄胎儿胃的表面黏液细胞和腺细胞中也存在高水平的GST-pi，而成年胃中仅胃底腺的壁细胞显示出轻微的GST-pi染色。这些结果表明，GST-pi在人胃癌中的表型表达具有肿瘤胎儿性特征。
