Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders.

BACKGROUND

Child sexual abuse (CSA) is an important problem worldwide. The reason of sex abuse is considered as multifactorial. Genetic contribution reported by recent studies is a significant evidence for this pathologic behavior. Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. polymorphism causes functional changes in enzyme activity. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor usually synthesized from central nervous system neurons. With the effect of BDNF, dopamine and serotonin play important roles on neurogenesis, survival, and synaptic plasticity.

AIM

This study aims to examine Val158Met (rs4680) and Val66Met (rs6265) polymorphisms in CSA.

SETTINGS AND DESIGN

This was a case-control study.

MATERIALS AND METHODS

Seventy paraphilic child sexual abuser patients and seventy age- and gender-matched healthy controls participated in this study. Val158Met and Val66Met polymorphisms were genotyped by real-time polymerase chain reaction assay.

RESULTS

COMT Val158Met genotype frequencies were determined as GG 31.4%, GA 45.7%, and AA 22.9% in patients; GG 24.3%, GA 45.7%, and AA 8.6% in controls; and exhibited a positive relationship between the groups ( = 0.018). Val66Met genotype frequencies were determined as GG 77.1%, GA 21.4%, and AA 1.4% in patients; GG 65.7%, GA 31.4%, AA 2.9% in controls; and no significant relationship was observed between the groups ( = 0.317).

CONCLUSIONS

This research investigated (Val158Met) and (Val66Met) in paraphilic child sexual offenders. A positive relationship was found for gene; however, no significant relation was observed for gene between paraphilic sexual offenders and controls.