Pedrazzini T, Hug K, Louis J A
J Immunol. 1987 Sep 15;139(6):2032-7.
The course of infection after injection of small doses of bacillus Calmette-Guérin (BCG) was studied in mice which were depleted in vivo of T cell subsets by administration of either anti-L3T4 or anti-Lyt-2 mAb. The results presented herein strongly suggest that the L3T4+ subpopulation play a pivotal role in the immunologic control of BCG infection because the depletion of L3T4+ cells led to a dramatic increase in the number of viable bacteria. Depletion of Lyt-2+ cells had no significant effect on the course of infection. These results were confirmed by using adoptive transfer experiments which showed that protective immunity was mediated by L3T4+ cells generated in the spleen as a result of infection. Moreover, T cells capable of controlling the recurrence of BCG multiplication from residual bacteria remaining in organs after the recovery from infection were shown to belong to the L3T4+ subpopulation.
通过给予抗L3T4或抗Lyt-2单克隆抗体在体内使T细胞亚群耗竭的小鼠，研究了注射小剂量卡介苗（BCG）后的感染过程。本文给出的结果强烈表明，L3T4+亚群在BCG感染的免疫控制中起关键作用，因为L3T4+细胞的耗竭导致活菌数量急剧增加。Lyt-2+细胞的耗竭对感染过程没有显著影响。这些结果通过过继转移实验得到证实，该实验表明保护性免疫是由感染后脾脏中产生的L3T4+细胞介导的。此外，能够控制感染恢复后器官中残留细菌引起的BCG繁殖复发的T细胞被证明属于L3T4+亚群。
