Chudwin D S, Artrip S G, Ogden J D, Schiffman G
J Med Primatol. 1987;16(4):249-60.
Tamarins (Saguinus labiatus) were utilized to study host defenses against pneumococcal bacteremia. Tamarins had a poor antibody response to immunization with varying doses of pneumococcal capsular polysaccharide (PCP) vaccine (2 of 15 positive) or to infection with serotype 7F Streptococcus pneumoniae (2 of 14 positive). Tamarins were protected against challenge with a lethal dose of serotype 7F S. pneumoniae if the bacteria were preopsonized with human immune globulin intravenous or if the tamarins were injected with the immune globulin 30 min before challenge. There was minimal protection utilizing a mouse monoclonal anti-type 7F PCP antibody.
绢毛猴（白唇绢毛猴）被用于研究宿主对肺炎球菌菌血症的防御机制。绢毛猴对不同剂量的肺炎球菌荚膜多糖（PCP）疫苗免疫（15只中有2只呈阳性）或对7F血清型肺炎链球菌感染（14只中有2只呈阳性）的抗体反应较差。如果用静脉注射用人免疫球蛋白对细菌进行调理，或者在攻击前30分钟给绢毛猴注射免疫球蛋白，则绢毛猴可免受致死剂量的7F血清型肺炎链球菌攻击。使用小鼠抗7F型PCP单克隆抗体的保护作用微乎其微。
