Department of Neurology, The Second Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.
Department of Medical Imaging, The Second Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.
Neurol Sci. 2019 Oct;40(10):2097-2103. doi: 10.1007/s10072-019-03947-8. Epub 2019 May 30.
The aim of our study is to determine the pathological changes of white matter microstructure in patients with early post-stroke depression (PSD), and to investigate the association between white matter integrity examined by diffusion kurtosis imaging (DKI) and early PSD. Thirty-eight patients with acute cerebral infarction were selected, including 17 patients with depression (PSD group), and 21 patients without depression (N-PSD group). In addition, 20 normal healthy controls (NORM group) were selected. All were taken DKI scans. The white matter of the frontal lobe, temporal lobe, parietal lobe, occipital lobe, anterior limb of internal capsule, and posterior limb of internal capsule, in addition to the genu of corpus callosum and splenium of corpus callosum was selected as a region of interest (ROI). Selected parameters include fractional anisotropy (FA) and mean kurtosis (MK). Compared with N-PSD group and NORM group, FA value of the left frontal lobe and MK value of the bilateral frontal lobe, bilateral temporal lobe, and genu of corpus callosum in PSD group were decreased (P < 0.05). Our results indicated that the early PSD patients had white matter microstructure abnormalities in the frontal lobe, temporal lobe, and genu of corpus callosum. DKI provides a comprehensive brain imaging reference for detecting early microstructural damage of white matter in PSD patients, which can be used as an imaging biomarker to detect early PSD and its progression potentially.
我们的研究目的是确定早期卒中后抑郁（PSD）患者的脑白质微观结构变化，并探讨扩散峰度成像（DKI）检测到的脑白质完整性与早期 PSD 的关系。选择 38 例急性脑梗死患者，其中抑郁患者 17 例（PSD 组），无抑郁患者 21 例（非 PSD 组），另选 20 例正常健康对照者（NORM 组），均进行 DKI 扫描。选取额、颞、顶、枕叶，内囊前肢、后肢及胼胝体膝部、压部作为感兴趣区（ROI）。选择的参数包括各向异性分数（FA）和平均峰度（MK）。与 N-PSD 组和 NORM 组相比，PSD 组左侧额叶 FA 值及双侧额叶、双侧颞叶、胼胝体膝部 MK 值均降低（P＜0.05）。结果表明，早期 PSD 患者额叶、颞叶和胼胝体膝部存在脑白质微观结构异常。DKI 为检测 PSD 患者早期脑白质微观结构损伤提供了全面的脑影像学参考，可作为潜在的早期 PSD 及其进展的影像学生物标志物。
