Wade W F, Dees C, German T L, Marsh R F
Am J Vet Res. 1987 Jul;48(7):1077-81.
Preparations of brain plasma membrane from scrapie-infected or noninfected hamsters were extracted with a solvent and were used to inoculate rabbits. Antisera evaluated by immunoblot analysis revealed a protein of 45 kD in scrapie-infected hamster brain that had a greater signal compared with proteins of comparable relative mass in noninfected brain. This 45-kD protein was not increased in scrapie-infected mouse, sheep, or goat brain. Seemingly, the 45-kD protein may be a degradation product of glial fibrillary acidic protein.
用溶剂提取来自感染或未感染瘙痒病的仓鼠的脑质膜制剂，并用于接种兔子。通过免疫印迹分析评估的抗血清显示，感染瘙痒病的仓鼠脑中有一种45kD的蛋白质，与未感染脑中相对分子质量相当的蛋白质相比，其信号更强。在感染瘙痒病的小鼠、绵羊或山羊脑中，这种45kD的蛋白质并没有增加。看来，这种45kD的蛋白质可能是胶质纤维酸性蛋白的降解产物。
