Perfusion Department, BC Children's Hospital, Vancouver, British Columbia, Canada.
Perfusion Department, BC Children's Hospital, Vancouver, British Columbia, Canada.
J Cardiothorac Vasc Anesth. 2020 Feb;34(2):483-488. doi: 10.1053/j.jvca.2019.05.007. Epub 2019 May 11.
In the last few decades, the use of umbilical cord blood (UCB) has received increasing attention, not only as a source of stem cells, but also as a transfusion product for the treatment of anemia in the neonatal and even the adult population. This review focuses on data reports and collection efforts related to the autologous transfusion of UCB in full-term neonates with prenatally diagnosed critical congenital heart defects. This review summarizes different aspects of UCB transfusion, including indications and contraindications; the collection procedure; storage timing; and special properties of one of its constituents, fetal hemoglobin, in the setting of hypothermic cardiopulmonary bypass.
在过去的几十年中，脐带血（UCB）的应用受到了越来越多的关注，不仅作为干细胞的来源，而且还作为新生儿甚至成人贫血治疗的输血产品。这篇综述主要关注与产前诊断为严重先天性心脏缺陷的足月新生儿自体 UCB 输注相关的数据报告和收集工作。本文综述了 UCB 输注的不同方面，包括适应证和禁忌证；采集程序；储存时机；以及在低温心肺转流环境下其成分之一胎儿血红蛋白的特殊性质。
