Pediatric Translational Medicine Institute, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
BMJ Open. 2019 May 30;9(5):e028738. doi: 10.1136/bmjopen-2018-028738.
Low birth weight (BW) is a general symbol of inadequate intrauterine conditions that elicit abnormal fetal growth and development. The aim of current study is to investigate the relationship between low BW and thinness or severe obesity during maturation.
A large-scale cross-sectional population-based survey.
134 kindergartens and 70 elementary schools.
70 284 Chinese children aged 3-12 years.
International Obesity Task Force body mass index (BMI) cut-offs were used to define grade 1, grade 2 and grade 3 thinness, overweight, obesity and severe obesity. Multinomial logistic regression was used to estimate the association between BW and BMI category.
A total of 70 284 children participated in the survey. The percentage of grade 1 thinness and severe obesity in children with low BW is significantly higher than that in children with normal BW (p<0.05). Low BW was associated with an increased risk of grade 1 thinness (OR 1.56, 95% CI 1.38 to 1.75), grade 2 thinness (OR 1.34, 95% CI 1.10 to 1.64), grade 3 thinness (OR 1.99, 95% CI 1.63 to 2.42) and severe obesity (OR 1.27, 95% CI 1.03 to 1.55) but was not associated with obesity (OR 0.85, 95% CI 0.67 to 1.06).
There is a positive association between low BW and thinness or severe obesity risk.
低出生体重（BW）是宫内环境不良的一般标志，会引起胎儿生长和发育异常。本研究旨在探讨低 BW 与成熟过程中消瘦或严重肥胖之间的关系。
大规模的横断面人群为基础的调查。
134 所幼儿园和 70 所小学。
70284 名 3-12 岁的中国儿童。
使用国际肥胖工作组（IOTF）的体重指数（BMI）切点来定义消瘦 1 级、消瘦 2 级、消瘦 3 级、超重、肥胖和严重肥胖。采用多变量逻辑回归估计 BW 与 BMI 类别之间的关系。
共有 70284 名儿童参加了调查。低 BW 儿童消瘦 1 级和严重肥胖的比例明显高于正常 BW 儿童（p<0.05）。低 BW 与消瘦 1 级（OR 1.56，95%CI 1.38-1.75）、消瘦 2 级（OR 1.34，95%CI 1.10-1.64）、消瘦 3 级（OR 1.99，95%CI 1.63-2.42）和严重肥胖（OR 1.27，95%CI 1.03-1.55）的风险增加相关，但与肥胖（OR 0.85，95%CI 0.67-1.06）无关。
低 BW 与消瘦或严重肥胖风险呈正相关。
