雄激素受体易位的关键。
Keys to unlock androgen receptor translocation.
机构信息
From Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 1L3, Canada.
From Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 1L3, Canada
出版信息
J Biol Chem. 2019 May 31;294(22):8711-8712. doi: 10.1074/jbc.H119.009180.
Abstract
The androgen receptor (AR) is tightly linked to prostate cancer, but the mechanisms by which AR transactivation is dysregulated during cancer progression are not fully explored. Dagar examined AR translocation to the nucleus to identify a link between heat shock protein 90 (HSP90) and protein kinase A (PKA). Their findings provide a potential mechanism of the initiation of AR transactivation and potential targets for developing and refining treatments for prostate cancer.
摘要
雄激素受体（AR）与前列腺癌密切相关，但在癌症进展过程中 AR 转录激活失调的机制尚未完全探索。Dagar 研究了 AR 向核内易位，以确定热休克蛋白 90（HSP90）和蛋白激酶 A（PKA）之间的联系。他们的发现为 AR 转录激活的启动提供了一个潜在机制，并为开发和完善前列腺癌治疗方法提供了潜在靶点。
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本文引用的文献
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Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor.蛋白激酶 A 对 HSP90 的磷酸化对于雄激素受体的核转位是必不可少的。
J Biol Chem. 2019 May 31;294(22):8699-8710. doi: 10.1074/jbc.RA119.007420. Epub 2019 Apr 16.
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Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness.环磷酸腺苷依赖性蛋白激酶催化亚基Cβ2的表达水平与前列腺癌侵袭性之间的观察到的相关性。
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Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer.蛋白激酶 A (PKA) 通路在前列腺癌的进展中与雄激素受体 (AR) 在功能上相关联。
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9
Regulation of the 5'-flanking region of the mouse androgen receptor gene by cAMP and androgen.环磷酸腺苷（cAMP）和雄激素对小鼠雄激素受体基因5'侧翼区域的调控
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