Department of Orthopedics, the Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China.
Department of Geriatrics, Jinling Hospital, Medical School of Nanjing University, Nanjing, 211002, China.
Neuroscience. 2019 Jul 15;411:177-184. doi: 10.1016/j.neuroscience.2019.05.038. Epub 2019 May 30.
Angiopoietin (Ang) is an angiogenic factor, but its neuroprotective and neurotrophic effects have recently come to light. Ang exerts neuroprotective effects by inhibiting neuronal apoptosis, protecting the blood-brain/blood-spinal cord barrier, reducing inflammation and promoting neovascularization. In addition, Ang can also promote neural development and neurite outgrowth via activation of the PI3K/Akt signaling pathway and binding to the Tie2 receptor and/or integrin receptor. In addition, Ang and vascular endothelial growth factor (VEGF) are known to interact in blood vessels in the nervous system and the combination of Ang and VEGF can mitigate the negative effects of VEGF, such as inflammation and local edema. These data indicated that Ang is a novel neuroprotective/neurotrophic factor, which may become a new tool for the treatment of nerve injury.
血管生成素 (Ang) 是一种血管生成因子，但它的神经保护和神经营养作用最近才被发现。Ang 通过抑制神经元凋亡、保护血脑/血脊髓屏障、减少炎症和促进血管新生来发挥神经保护作用。此外，Ang 还可以通过激活 PI3K/Akt 信号通路并与 Tie2 受体和/或整合素受体结合，促进神经发育和神经突生长。此外，已知血管生成素和血管内皮生长因子 (VEGF) 在神经系统的血管中相互作用，Ang 和 VEGF 的结合可以减轻 VEGF 的负面效应，如炎症和局部水肿。这些数据表明 Ang 是一种新型的神经保护/神经营养因子，可能成为治疗神经损伤的新工具。
