Istinye University, Faculty of Medicine, LIV Hospital, Department of Rheumatology, Turkey.
Okan University, Faculty of Medicine, Department of Chest Diseases, Turkey.
Reumatol Clin (Engl Ed). 2021 Jan;17(1):49-51. doi: 10.1016/j.reuma.2019.04.003. Epub 2019 May 29.
The relationship between sarcoidosis and malignancy is not clear yet. We retrospectively evaluated 131 sarcoidosis patients followed-up at the single Rheumatology center. The incidence of malignancies was investigated in this cohort. A total of 6 (4.6%) patients with malignancy were identified in our cohort of 131 patients with sarcoidosis. Hodgkin lymphoma (HL) was detected in three patients, followed by one patient with breast cancer, one patient with thyroid cancer and one patient with testicular cancer. All patients had chronic sarcoidosis with pulmonary involvement, and only 1 patient had acute sarcoidosis with Löfgren's syndrome. HL developed concomitantly with sarcoidosis in one patient while other two patients developed disease before and after sarcoidosis diagnosis. Two patients with solid tumors developed malignancy years before sarcoidosis diagnosis, while one patient developed thyroid cancer during sarcoidosis follow-up. All 6 sarcoidosis-malignancy patients survived after six year years follow up. We found low incidence of malignancy in patients with sarcoidosis in our small cohort. The sarcoidosis-malignancy relationship can only be a coincidence and/or can be explained by a common pathogenesis. New prospective studies involving large patients series are needed in this regard.
结节病和恶性肿瘤之间的关系尚不清楚。我们回顾性评估了在单一风湿病中心随访的 131 例结节病患者。在该队列中研究了恶性肿瘤的发病率。在我们的 131 例结节病患者队列中，共发现 6（4.6%）例恶性肿瘤患者。三例患者被诊断为霍奇金淋巴瘤（HL），随后一例患者被诊断为乳腺癌，一例患者被诊断为甲状腺癌，一例患者被诊断为睾丸癌。所有患者均患有伴有肺部受累的慢性结节病，仅 1 例患者患有急性结节病伴有 Löfgren 综合征。1 例患者的 HL 与结节病同时发生，另外 2 例患者的 HL 在结节病诊断之前和之后发生。2 例实体瘤患者在结节病诊断前多年就发生了恶性肿瘤，而 1 例患者在结节病随访期间发生了甲状腺癌。所有 6 例结节病合并恶性肿瘤的患者在 6 年随访后均存活。我们发现，我们的小队列中结节病患者的恶性肿瘤发病率较低。结节病和恶性肿瘤之间的关系只能是巧合，或者可以用共同的发病机制来解释。在这方面需要进行新的、涉及大量患者系列的前瞻性研究。
