Leiden University Medical Centre (LUMC), Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Radiology Department, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Skeletal Radiol. 2019 Dec;48(12):1905-1914. doi: 10.1007/s00256-019-03227-8. Epub 2019 Jun 1.
To determine the image quality of fast spin echo (FSE) with mDixon relative to spectral attenuated inversion recovery (SPAIR) FSE sequences in musculoskeletal tumor imaging on a 1.5-T MRI system.
In a HIPAA-compliant prospective study, 265 patients requiring musculoskeletal tumor MRI scans were included. Patient consent was waived by the medical ethical committee. Two radiologists compared SPAIR and mDixon FSE water-only images in both T2- and T1-weighted gadolinium-enhanced (T1-Gd) sequences using a five-point scale (paired samples t test and visual grading characteristics curves (VGC)). Homogeneity of fat suppression, noise, contrast, several artifacts (motion, phase, edge blurring and water-fat swap) and subjective preference were evaluated.
Readers did not have subjective preference for either sequence in 71% and 55% (reader 1 and 2, respectively). Scores for homogeneous fat suppression were significantly (p < 0.01) higher for mDixon (4.88 in T2 and 4.87 in T1-Gd) than for SPAIR (4.31 for T2 and 4.21 for T1-Gd). All VGC curves for homogeneity demonstrated preference for mDixon. In 57 individual mDixon cases, fat-suppression homogeneity was strikingly better (≥ 2 points higher), namely in areas with field heterogeneity. Average noise and contrast scores were slightly higher for mDixon, as were motion artifact scores for SPAIR (< 0.5 points difference).
mDixon fat suppression was significantly more homogeneous than SPAIR on both T2 and T1-Gd FSE images in musculoskeletal tumor protocols. In areas of field inhomogeneity, mDixon outperforms SPAIR. SPAIR had slightly less motion artifacts than mDixon.
在 1.5T MRI 系统上，比较快速自旋回波（FSE）与 mDixon 相对谱衰减反转恢复（SPAIR）FSE 序列在肌肉骨骼肿瘤成像中的图像质量。
在符合 HIPAA 标准的前瞻性研究中，纳入 265 例需要进行肌肉骨骼肿瘤 MRI 扫描的患者。医疗伦理委员会豁免了患者的同意。两名放射科医生使用五分制对 SPAIR 和 mDixon FSE 水成像在 T2 加权和钆增强 T1 加权（T1-Gd）序列中的图像（配对样本 t 检验和视觉分级特征曲线（VGC））进行比较。评估了均匀性（脂肪抑制、噪声、对比度、多种伪影（运动、相位、边缘模糊和水-脂交换）和主观偏好。
两位放射科医生分别有 71%和 55%的患者对两种序列无主观偏好。在 T2 和 T1-Gd 中，mDixon 的均匀脂肪抑制评分（4.88 和 4.87）明显高于 SPAIR（4.31 和 4.21）（p < 0.01）。所有 T2 和 T1-Gd 中，均匀性的 VGC 曲线都偏好 mDixon。在 57 例单独的 mDixon 病例中，脂肪抑制的均匀性明显更好（高 2 分以上），即在磁场不均匀的区域。mDixon 的平均噪声和对比度评分稍高，而 SPAIR 的运动伪影评分稍低（差异小于 0.5 分）。
在肌肉骨骼肿瘤方案的 T2 和 T1-Gd FSE 图像中，mDixon 脂肪抑制明显比 SPAIR 更均匀。在磁场不均匀的区域，mDixon 优于 SPAIR。mDixon 的运动伪影略少于 SPAIR。
