College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, 610500, People's Republic of China.
State Key Laboratory of Oil & Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, 610500, People's Republic of China.
Mikrochim Acta. 2019 Jun 1;186(6):395. doi: 10.1007/s00604-019-3458-x.
This review (with 239 refs.) summarizes the progress that has been made in applications of graphene-based nanomaterials (such as plain graphene, graphene oxides, doped graphene oxides, graphene quantums dots) in biosensing, imaging, drug delivery and diagnosis. Following an introduction into the field, a first large section covers the toxicity of graphene and its derivatives (with subsections on bacterial toxicity and tissue toxicity). The use of graphene-based nanomaterials in sensors is reviewed next, with subsections on electrochemical, FET-based, fluorescent, chemiluminescent and colorimetric sensors and probes. The large field of imaging is treated next, with subchapters on optical, PET-based, and magnetic resonance based methods. A concluding section summarizes the current status, addresses current challenges, and gives an outlook on potential future trends. Graphical Abstract Schematic presentation of the potential applications of graphene-based materials in life science and biomedicine, emphatically reflected in some vital areas such as DNA analysis, biological monitoring, drug delivery, in vitro labelling, in vivo imaging, tumor target, etc.
这篇综述（引用了 239 篇参考文献）总结了基于石墨烯的纳米材料（如普通石墨烯、氧化石墨烯、掺杂氧化石墨烯、石墨烯量子点）在生物传感、成像、药物输送和诊断中的应用进展。在介绍该领域之后，首先涵盖了石墨烯及其衍生物的毒性（分为细菌毒性和组织毒性两个部分）。接下来，我们回顾了基于石墨烯的纳米材料在传感器中的应用，包括电化学、FET 基、荧光、化学发光和比色传感器和探针。接下来是成像这个大领域，包括光学、基于 PET 和磁共振的方法。最后一节总结了当前的现状，讨论了当前的挑战，并展望了未来潜在的趋势。
