Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Health Science Center, Ningbo University, Ningbo, China.
Sci Prog. 2024 Oct-Dec;107(4):368504241291342. doi: 10.1177/00368504241291342.
Head and neck cancer (HNC) is the sixth most common cancer in the world, and its incidence is increasing year by year. Due to the late-stage diagnosis and poor prognosis of HNC, as well as the limitations of traditional treatment methods, it is urgent to improve early detection rates and explore alternative treatment approaches. Graphene-based nanomaterials (GBNs) have been widely applied in biomedical fields due to their high surface area, excellent photothermal properties, and high loading capacity. This literature review introduces the functionalization and biocompatibility of GBNs, followed by a focus on their applications in the diagnosis and treatment of HNC. This includes their potential as bioimaging or biosensing platforms for diagnosis and monitoring, as well as their research progress in chemotherapy drug delivery, phototherapy, and gene transfection. The tremendous potential of GBNs as a platform for combination therapies is emphasized. Finally, in this literature review, we briefly discuss the toxicity and limitations of GBNs in the current research and provide an outlook on their future clinical applications in the diagnosis and treatment of HNC.
头颈部癌症（HNC）是世界上第六种最常见的癌症，其发病率呈逐年上升趋势。由于 HNC 的诊断晚期和预后不良，以及传统治疗方法的局限性，迫切需要提高早期检出率并探索替代治疗方法。基于石墨烯的纳米材料（GBNs）由于其高表面积、优异的光热性能和高载药能力，已广泛应用于生物医学领域。本文综述介绍了 GBNs 的功能化和生物相容性，然后重点介绍了它们在 HNC 的诊断和治疗中的应用。这包括它们作为生物成像或生物传感平台用于诊断和监测的潜力，以及它们在化疗药物输送、光疗和基因转染方面的研究进展。强调了 GBNs 作为联合治疗平台的巨大潜力。最后，在本文综述中，我们简要讨论了 GBNs 在当前研究中的毒性和局限性，并对它们在 HNC 的诊断和治疗中的未来临床应用进行了展望。
