亲核芳基化：烷氧基甲基三苯膦盐的显著应用。

Nucleophilic phenylation: a remarkable application of alkoxymethyltriphenylphosphonium salts.

机构信息

Department of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.

H.E.J. Research Institute of Chemistry, ICCBS, University of Karachi, Karachi, 75270, Pakistan.

出版信息

Mol Divers. 2020 May;24(2):455-462. doi: 10.1007/s11030-019-09966-z. Epub 2019 Jun 1.

DOI:10.1007/s11030-019-09966-z

PMID:31154589

Abstract

A new application of α-alkoxymethylphosphonium salts in the nucleophilic phenylation of carbonyl compounds is demonstrated. Phenylation of aldehydes, ketones and acyl halides were studied by employing α-alkoxymethyltriphenylphosphonium halides in the presence of lithium hydroxide. New application of α-alkoxymethyltriphenylphosphonium salts. Metal-free, mild and selective phenylation. Easy preparation and handling of the reagent.

摘要

本文展示了α-烷氧基甲基膦盐在羰基化合物的亲核芳基化反应中的新应用。通过使用α-烷氧基甲基三苯基卤化膦在氢氧化锂的存在下，研究了醛、酮和酰卤的芳基化反应。α-烷氧基甲基三苯基膦盐的新应用。无金属、温和、选择性的芳基化。试剂的制备和处理简单。