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[慢性、非病原体相关性睾丸炎]

[Chronic, nonpathogen-related orchitis].

作者信息

Hofmann N, Kuwert E

出版信息

Z Hautkr. 1979 Mar 1;54(5):173-80.

PMID:311554
Abstract

Chronic non-infectious orchitis was found in 8.1% of fertility-patients, who underwent testicular biopsy because of severe disturbances in spermatogenesis. The histopathological findings were characterized by a membraneous and interstitial orchitis. In these cases, the cause of the disease was unknown; but immunological abnormalities were found suggesting an imbalance of cell-mediated immune responses: all cases of chronic non-infectious orchitis showed a significant T-cell-deficiency.

摘要

在8.1%的不育患者中发现了慢性非感染性睾丸炎,这些患者因精子发生严重紊乱而接受了睾丸活检。组织病理学检查结果的特征为膜性和间质性睾丸炎。在这些病例中,病因不明;但发现了免疫异常,提示细胞介导的免疫反应失衡:所有慢性非感染性睾丸炎病例均显示出明显的T细胞缺陷。

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引用本文的文献

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Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice?感染性、炎症性和“自身免疫性”男性因素不孕:啮齿动物模型如何为临床实践提供信息?
Hum Reprod Update. 2018 Jul 1;24(4):416-441. doi: 10.1093/humupd/dmy009.
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Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice.在实验性自身免疫性附睾睾丸炎的过程中,小鼠的睾丸激活素和卵泡抑素水平升高。
Sci Rep. 2017 Feb 13;7:42391. doi: 10.1038/srep42391.
3
Experimental autoimmune orchitis as a model of immunological male infertility.
实验性自身免疫性睾丸炎作为免疫性男性不育的模型。
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Postinflammation stage of autoimmune orchitis induced by immunization with syngeneic testicular germ cells alone in mice.仅用同基因睾丸生殖细胞免疫诱导的小鼠自身免疫性睾丸炎的炎症后阶段
Med Mol Morphol. 2012 Dec;45(1):35-44. doi: 10.1007/s00795-011-0539-2. Epub 2012 Mar 20.
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Treatment of male fertility disturbances. Current concepts.
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Guidelines for drug treatment of male infertility.男性不育症药物治疗指南。
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