Tung K S, Umland E, Matzner P, Nelson K, Schauf V, Rubin L, Wagner D, Scollard D, Vithayasai P, Vithayasai V
Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131.
Clin Exp Immunol. 1987 Jul;69(1):10-5.
Soluble interleukin 2 receptors (IL-2R) in sera of leprosy patients from Chiang Mai, Thailand, were quantified with a solid phase enzyme immunoassay using two monoclonal antibodies to the IL-2R. The IL-2R levels of untreated lepromatous, borderline lepromatous or midborderline patients and treated lepromatous and borderline lepromatous or treated borderline tuberculoid and tuberculoid patients were comparable to those of the Thai household or nonhousehold contacts; and they were significantly higher than the levels of USA control subjects. In contrast, IL-2R of untreated tuberculoid or borderline tuberculoid patients were significantly reduced. Patients with ongoing reversal reaction had very high circulating IL-2R, the levels of which correlated with fever and extent of skin lesions. Although erythema nodosum leprosum patients also had elevated IL-2R levels, they were significantly below those of patients with reversal reaction. When treated with corticosteroid, precipitous reduction of IL-2R was noted in all patients with reversal reaction but not in patients with erythema nodosum leprosum.
采用针对白细胞介素2受体（IL-2R）的两种单克隆抗体，通过固相酶免疫测定法定量检测了来自泰国清迈的麻风病患者血清中的可溶性IL-2R。未经治疗的瘤型、界线类偏瘤型或中间界线类患者以及经治疗的瘤型、界线类偏瘤型或经治疗的界线类偏结核样型和结核样型患者的IL-2R水平与泰国家庭或非家庭接触者的水平相当；且显著高于美国对照受试者的水平。相比之下，未经治疗的结核样型或界线类偏结核样型患者的IL-2R水平显著降低。正在发生逆转反应的患者循环IL-2R水平非常高，其水平与发热及皮肤损害程度相关。虽然麻风结节性红斑患者的IL-2R水平也有所升高，但显著低于逆转反应患者的水平。用皮质类固醇治疗时，所有发生逆转反应的患者的IL-2R均急剧下降，但麻风结节性红斑患者未出现这种情况。
