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药物洗脱支架的涂层技术与释放动力学

Coating Techniques and Release Kinetics of Drug-Eluting Stents.

作者信息

Livingston Megan, Tan Aaron

机构信息

Department of Regenerative Medicine and Orthopaedics, Houston Methodist Research Institute, Houston, USA.

Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, UCL Medical School, University College London (UCL), London, UK.

出版信息

J Med Device. 2019 May 4;10(1). doi: 10.1115/1.4031718. Epub 2015 Nov 5.

DOI:10.1115/1.4031718
PMID:31156736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6542673/
Abstract

Implantation of drug-eluting stents (DESs) via percutaneous coronary intervention is the most popular treatment option to restore blood flow to occluded vasculature. The many devices currently used in clinic and under examination in research laboratories are manufactured using a variety of coating techniques to create the incorporated drug release platforms. These coating techniques offer various benefits including ease of use, expense of equipment, and design variability. This review paper discusses recent novel DES designs utilizing individual or a combination of these coating techniques and their resulting drug release profiles.

摘要

通过经皮冠状动脉介入植入药物洗脱支架（DESs）是恢复闭塞血管血流的最常用治疗选择。目前临床使用和研究实验室正在研究的许多装置都是采用多种涂层技术制造的，以创建内置的药物释放平台。这些涂层技术具有多种优点，包括使用方便、设备成本和设计可变性。本文综述讨论了利用这些涂层技术中的一种或多种组合的最新新型DES设计及其产生的药物释放曲线。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/5369da6f5510/EMS82790-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/125b443007f9/EMS82790-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/2b33d0912e17/EMS82790-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/3b2e7053d9c2/EMS82790-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/9193148e19d6/EMS82790-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/5369da6f5510/EMS82790-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/125b443007f9/EMS82790-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/2b33d0912e17/EMS82790-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/3b2e7053d9c2/EMS82790-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/9193148e19d6/EMS82790-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b130/6542673/5369da6f5510/EMS82790-f005.jpg

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本文引用的文献

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Paclitaxel-loaded poly(lactide-co-glycolide)/poly(ethylene vinyl acetate) composite for stent coating by ultrasonic atomizing spray.用于支架涂层的载紫杉醇聚（丙交酯-共-乙交酯）/聚（乙烯-醋酸乙烯酯）复合材料的超声雾化喷涂
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