药物洗脱支架的涂层技术与释放动力学
Coating Techniques and Release Kinetics of Drug-Eluting Stents.
作者信息
Livingston Megan, Tan Aaron
机构信息
Department of Regenerative Medicine and Orthopaedics, Houston Methodist Research Institute, Houston, USA.
Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, UCL Medical School, University College London (UCL), London, UK.
出版信息
J Med Device. 2019 May 4;10(1). doi: 10.1115/1.4031718. Epub 2015 Nov 5.
Abstract
Implantation of drug-eluting stents (DESs) via percutaneous coronary intervention is the most popular treatment option to restore blood flow to occluded vasculature. The many devices currently used in clinic and under examination in research laboratories are manufactured using a variety of coating techniques to create the incorporated drug release platforms. These coating techniques offer various benefits including ease of use, expense of equipment, and design variability. This review paper discusses recent novel DES designs utilizing individual or a combination of these coating techniques and their resulting drug release profiles.
摘要
通过经皮冠状动脉介入植入药物洗脱支架（DESs）是恢复闭塞血管血流的最常用治疗选择。目前临床使用和研究实验室正在研究的许多装置都是采用多种涂层技术制造的，以创建内置的药物释放平台。这些涂层技术具有多种优点，包括使用方便、设备成本和设计可变性。本文综述讨论了利用这些涂层技术中的一种或多种组合的最新新型DES设计及其产生的药物释放曲线。
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