Shapouri-Moghaddam Abbas, Saeed Modaghegh Mohammad-Hadi, Rahimi Hamid Reza, Ehteshamfar Seyyed-Morteza, Tavakol Afshari Jalil
Immunology Research Group, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Vascular and Endovascular Surgery Research Center, Alavi Hospital, Mashhad University of Medical Sciences, Iran.
Iran J Basic Med Sci. 2019 Mar;22(3):215-224. doi: 10.22038/ijbms.2019.31119.7513.
Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still unclear. This review was intended to collate the more current knowledge on the regulatory molecules involved in TAO from an immunoreactive perspective. The homeostasis of the immune system as well as a variety of progenitor cell populations appear to be affected during TAO and these alterations are associated with intrinsic signaling defects that are directing to an improved understanding of the crosstalk between angiogenesis and the immune system, as well as the potential of new co-targeting strategies applying both immunotherapy and angiogenic therapy.
血栓闭塞性脉管炎（TAO）是一种病因不明的血栓闭塞性及炎症性外周血管疾病。最近的证据支持了该疾病的免疫发病机制，然而，导致免疫功能改变和血管组织炎症的因素仍不清楚。本综述旨在从免疫反应的角度整理关于TAO中涉及的调节分子的最新知识。在TAO期间，免疫系统的稳态以及各种祖细胞群体似乎受到影响，这些改变与内在信号缺陷有关，这有助于更好地理解血管生成与免疫系统之间的相互作用，以及应用免疫疗法和血管生成疗法的新联合靶向策略的潜力。
