State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China; Department of Vascular and Thyroid Surgery of the Affiliated Hospital of Southwest Medical University, Sichuan Province, China.
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Atherosclerosis. 2017 Oct;265:258-265. doi: 10.1016/j.atherosclerosis.2017.08.009. Epub 2017 Aug 18.
Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental, inflammatory vasculitis, which commonly affects the small- and medium-sized arteries of the upper and lower extremities. Despite its discovery more than a century ago, little progress has been made in its treatment. Unless the pathogenesis is elucidated, therapeutic approaches will be limited. The purpose of this review article is to collate current knowledge of mechanisms for the pathogenesis of thromboangiitis obliterans and to propose potential mechanisms from a genetic and immunoreactive point of view for its inception. Therefore, we discuss the possibility that the pathogenesis of this disease is due to a type of gene polymorphism, which leads to an immunological inflammatory vasculitis associated with tobacco abuse, highly linked to T cells, human vascular endothelial cells (HVECs), and the TLR-MyD88-NFκB pathway, distinct from arteriosclerosis obliterans and other vasculitides.
血栓闭塞性脉管炎（TAO）是一种非动脉粥样硬化性、节段性、炎症性血管炎，通常影响上下肢的小动脉和中等动脉。尽管它在一个多世纪前就被发现了，但在治疗方面几乎没有取得进展。除非阐明发病机制，否则治疗方法将受到限制。本文综述的目的是整理目前对血栓闭塞性脉管炎发病机制的认识，并从遗传和免疫反应的角度提出其发病的潜在机制。因此，我们讨论了这种疾病的发病机制是否由于某种类型的基因多态性导致的，这种多态性导致与吸烟有关的免疫性炎症性血管炎，与 T 细胞、人血管内皮细胞（HVEC）和 TLR-MyD88-NFκB 途径密切相关，与动脉硬化闭塞症和其他血管炎不同。
