不同温度下储存在输液器中的昂丹司琼与氟哌啶醇混合物的稳定性。
Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures.
作者信息
Espinosa-Bosch María, Sanchez-Rojas Fuensanta, Bosch-Ojeda Catalina
机构信息
UGC Pharmacy, Regional University Hospital of Málaga, Málaga, Spain.
Department of Analytical Chemistry, Faculty of Sciences, University of Málaga, Málaga, Spain.
出版信息
Eur J Hosp Pharm. 2018 Oct;25(e2):e134-e138. doi: 10.1136/ejhpharm-2017-001412. Epub 2018 Jan 27.
BACKGROUND AND OBJECTIVE
Mixing different drugs for use in continuous infusion systems is a common practice in palliative care, but analytical study of compatibility and stability is not always available. The objective of this work is to study the stability of solutions of ondansetron and haloperidol at different concentrations and temperatures all prepared in 0.9% NaCl and stored in infusors, with all cases protected from light.
MATERIALS AND METHODS
The high performance liquid chromatography-Ultraviolet (HPLC-UV) method was employed for the determination of the drugs. The concentrations of the admixtures were 0.15-0.25 mg/mL and 0.3-0.4 mg/mL of haloperidol and ondansetron, respectively, with a storage temperature of 25°C and 37°C.
RESULTS
All solutions were initially clear and colourless, but visible particles appear, in all cases, into the infusers after 2 days since their preparation.
CONCLUSION
From the results obtained we can conclude that the mixtures prepared in the conditions previously described are stable less than 48 hours.
背景与目的
在姑息治疗中，将不同药物混合用于持续输注系统是一种常见做法，但兼容性和稳定性的分析研究并非总能获得。本研究的目的是研究在不同浓度和温度下，昂丹司琼和氟哌啶醇溶液在0.9%氯化钠中配制并储存在输液器中（所有情况均避光）的稳定性。
材料与方法
采用高效液相色谱 - 紫外（HPLC - UV）法测定药物。混合物中氟哌啶醇和昂丹司琼的浓度分别为0.15 - 0.25 mg/mL和0.3 - 0.4 mg/mL，储存温度为25°C和37°C。
结果
所有溶液最初均清澈无色，但自配制后2天起，所有输液器中的溶液均出现可见颗粒。
结论
从获得的结果可以得出结论，在上述条件下配制的混合物稳定性小于48小时。
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