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黎巴嫩一家三级医疗中心的细支气管炎住院情况:十年经验

Bronchiolitis Admissions in a Lebanese Tertiary Medical Center: A 10 Years' Experience.

作者信息

Naja Zeina, Fayad Danielle, Khafaja Sarah, Chamseddine Sarah, Dbaibo Ghassan, Hanna-Wakim Rima

机构信息

Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

出版信息

Front Pediatr. 2019 May 17;7:189. doi: 10.3389/fped.2019.00189. eCollection 2019.

Abstract

Bronchiolitis and more specifically respiratory syncytial virus (RSV) bronchiolitis is a leading cause of global childhood morbidity and mortality. Despite the previous identification of possible risk factors associated with the severity of bronchiolitis, the data from Lebanon remains limited. We described the burden of bronchiolitis hospitalizations in children under 5 years of age in a tertiary care center in Lebanon from October 2004 to October 2014 and identified the risk factors associated with severe bronchiolitis. This was a retrospective cohort study conducted at the American University of Beirut Medical Center. Records of children younger than 5 years of age admitted with a diagnosis of bronchiolitis were reviewed. More than half the patients were RSV positive. RSV bronchiolitis was found to be significantly associated with longer hospital stay compared to children with non-RSV bronchiolitis ( = 0.007). Children exposed to smoking had an increased risk for longer hospital stay ( = 0.002) and were more likely to require ICU admission ( < 0.001) and supplemental oxygen ( = 0.045). Congenital heart disease was found to be a significant risk factor for severe bronchiolitis ( < 0.005). Patients with RSV bronchiolitis had a longer hospital stay compared to patients with non-RSV bronchiolitis. Exposure to smoking was associated with a more severe and complicated RSV infection. Congenital heart disease was the only risk factor significantly associated with all markers of bronchiolitis disease severity.

摘要

细支气管炎,更具体地说是呼吸道合胞病毒(RSV)细支气管炎,是全球儿童发病和死亡的主要原因。尽管此前已确定了与细支气管炎严重程度相关的可能风险因素,但黎巴嫩的数据仍然有限。我们描述了2004年10月至2014年10月黎巴嫩一家三级护理中心5岁以下儿童细支气管炎住院的负担,并确定了与严重细支气管炎相关的风险因素。这是一项在贝鲁特美国大学医学中心进行的回顾性队列研究。对诊断为细支气管炎的5岁以下儿童的记录进行了审查。超过一半的患者RSV呈阳性。与非RSV细支气管炎患儿相比,RSV细支气管炎被发现与更长的住院时间显著相关(P = 0.007)。接触吸烟的儿童住院时间延长的风险增加(P = 0.002),更有可能需要入住重症监护病房(P < 0.001)和补充氧气(P = 0.045)。先天性心脏病被发现是严重细支气管炎的一个重要风险因素(P < 0.005)。与非RSV细支气管炎患者相比,RSV细支气管炎患者的住院时间更长。接触吸烟与更严重和复杂的RSV感染有关。先天性心脏病是与细支气管炎疾病严重程度的所有指标显著相关的唯一风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/6533463/807c3f5611f8/fped-07-00189-g0001.jpg

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