Department of Biochemistry, Medicine Faculty, Universidad Autónoma de San Luis Potosí, San Luis Potosí, PC 78210, Mexico.
MicroRNAs Laboratory, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, PC 98610, Mexico.
Biomark Med. 2019 Jun;13(8):675-684. doi: 10.2217/bmm-2018-0468. Epub 2019 Jun 3.
Exosomes are defined as extracellular vesicles that are released from cells upon fusion of an intermediate endocytic compartment - the multivesicular body - with the plasma membrane. Recently, placenta-derived exosomes have gained special attention, since they play a crucial role in the communication between the mother and fetus. It is known that the concentration of placenta-derived exosomes in the maternal bloodstream is higher in patients with preeclampsia or gestational diabetes mellitus. However, their composition in terms of the content of proteins, nucleic acids or lipids is uncertain. In this work, we reviewed the recent advances in placental exosomes characterization through omics-based methods, and their potential to predict gestational diabetes mellitus.
外泌体被定义为细胞在中间内吞体（多泡体）与质膜融合时释放的细胞外囊泡。最近，胎盘来源的外泌体引起了特别关注，因为它们在母胎之间的通讯中起着至关重要的作用。已知子痫前期或妊娠期糖尿病患者母血中胎盘来源的外泌体浓度较高。然而，它们在蛋白质、核酸或脂质含量方面的组成尚不确定。在这项工作中，我们通过基于组学的方法综述了胎盘外泌体特征的最新进展及其预测妊娠期糖尿病的潜力。
